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Updated: Feb 12, 2026

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诱导堕胎,流产和乳腺癌风险-芬兰的一项基于登记册的研究
Sushmita Katuwal1,2, Jaana Männistö3, Maarit Niinimäki3
1Unit of Health Sciences, Faculty of Social Medicine, Tampere University, Tampere, Finland.
Acta obstetricia et gynecologica Scandinavica
|February 11, 2026
概括
诱导性流产和流产史不会增加乳腺癌的风险. 这项大型芬兰注册研究发现,无论发生事件数量或年龄,绝经前或绝经后的女性都没有相关性.
科学领域:
- 生殖健康 生殖健康
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 诱导堕胎,流产和乳腺癌风险之间的关系是一个有争议的话题,经常被错误信息所掩盖.
- 此前关于这个问题的研究往往受到小样本大小和依赖自我报告数据的限制.
- 高质量的芬兰注册数据为严格评估这些协会提供了机会.
研究的目的:
- 调查诱导堕胎与乳腺癌风险之间的关联.
- 检查流产和乳腺癌风险之间的关联.
- 为了区分绝经前和绝经后妇女的风险.
主要方法:
- 一个基于人口的病例控制研究,利用芬兰国家注册数据.
- 包括31,687名患有乳腺癌的女性和158,433名匹配的对照.
- 收集关于诱导堕胎,流产,分娩,激素治疗,SES和职业的数据;使用多变量条件后勤回归分析.
主要成果:
- 在有先例诱导性流产的妇女中,没有观察到乳腺癌的几率比率 (OR) 增加 (绝经前OR: 1.00,绝经后OR: 0.95).
- 在有流产史的女性中,没有发现乳腺癌的OR增加 (绝经前OR:1.02,绝经后OR:0.92).
- 风险并没有因事件的数量或第一次事件时的年龄而有显著变化.
结论:
- 有过人工流产的病史与随后患乳腺癌的风险增加无关.
- 流产史与随后患乳腺癌的风险增加无关.
- 这些发现是正确的,不管事件的数量或事件发生时的女性年龄.
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