可见光诱导的 perfluoroalkylation 循环,通过 EDA 复合体获得 perfluoroalkylated benzazepines 和 benzoxepines 的使用
Anxu Pan1, Wanqing Zhao1, Cuifu Jiang1
1Key Laboratory of Functionalized Molecular Solids, Ministry of Education, Anhui Key Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui 241000, China. zhounn@ahnu.edu.cn.
概括
一种新的无光催化剂方法使得使用可见光合成 perfluoroalkylated benzazepines 和 benzoxepines 的合成成为可能. 这种环保策略提供了简单的操作和良好的区域选择性,用于创建七个成员的异循环.
科学领域:
- 有机化学 有机化学
- 合成化学 合成化学
- 药用化学 医学化学
背景情况:
- perfluoroalkylated heterocycles 是药物化学中的一个重要的支架.
- 它们的制备需要有效和环保的合成方法.
- 现有的方法通常需要恶劣的条件或昂贵的催化剂.
研究的目的:
- 开发一种新的,无光催化剂的方法来合成 perfluoroalkylated benzazepines 和benzoxepines.
- 建立一个环保和高效的战略,以获得七个成员的异环.
- 为了研究EDA复合体所启动的反应机制.
主要方法:
- 可见光介导的 perfluoroalkylation 和循环反应.
- 使用N--N-(2-(3,3-bis(甲基) 烯基) ) -4-甲基硫胺和1-(2-(基) -3-,3-bis(甲基) -2--1-作为基质.
- 使用碳酸 (K2CO3) 和 perfluoroalkyl 化物.
主要成果:
- 成功合成了 perfluoroalkylated benzazepines 和 benzoxepines 的合成.
- 该协议没有光催化剂,显示了简单的操作和良好的区域选择性.
- 预先的机制研究表明,EDA复合物的形成启动了反应.
结论:
- 开发了一种新的,环保的策略,用于合成七个成员的异环环.
- 开发的方法为获取 perfluoroalkylated benzazepines 和 benzoxepines 提供了一种可持续的替代方法.
- 无光催化剂的方法简化了合成过程,提高了区域选择性.
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