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相关概念视频

Steady State Concentration01:05

Steady State Concentration

6.1K
A steady state refers to the level of a drug in the body once it has reached an equilibrium between administration and elimination. It represents the point at which the drug administration rate equals the drug elimination rate, resulting in a relatively constant concentration in the body over time. The dynamic equilibrium is crucial to ensure the drug's effectiveness with minimal risk of toxicity.
Most drugs are administered in repeated doses at fixed intervals or through continuous...
6.1K
Expressing Solution Concentration02:48

Expressing Solution Concentration

69.2K
A solute is a component of a solution that is typically present at a much lower concentration than the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
Concentrations may be quantitatively assessed using a wide variety of measurement units, each convenient for particular applications. Molarity (M) is a useful concentration unit for many applications in chemistry.
69.2K
Solution Concentration and Dilution02:59

Solution Concentration and Dilution

135.2K
The relative amount of a given solution component is known as its concentration. Often, though not always, a solution contains one component with a concentration that is significantly greater than that of all other components. This component is called the solvent and may be viewed as the medium in which the other components are dispersed or dissolved. Solutions in which water is the solvent are, of course, very common on our planet. A solution in which water is the solvent is called an aqueous...
135.2K
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations01:15

Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations

261
Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...
261
Concentration Cells02:41

Concentration Cells

25.9K
A concentration cell is a type of a  voltaic cell constructed by connecting two almost identical half-cells, both based on the same half-reaction and using the same electrode, differing only in the concentration of one redox species. A concentration cell's potential, therefore, is determined only by the concentration difference of the particular redox species.
Consider the following voltaic cell:
25.9K
Steady Flow of a Fluid Stream01:27

Steady Flow of a Fluid Stream

773
Consider a control volume, such as a pipe with solid boundaries, through which fluid flows and changes direction due to the impulse exerted by the resulting force from the pipe walls. In steady flow, the mass of fluid entering the control volume at a given time, t, with velocity v1, is equal to the mass leaving after infinitesimal time dt, with velocity v2.
During this process, the momentum of the fluid within the control volume remains constant over the time interval dt. By applying the...
773

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Steady-state, Pre-steady-state, and Single-turnover Kinetic Measurement for DNA Glycosylase Activity
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使用封闭形式稳定状态溶液的分子度场设计.

Dong Woo Kim1, Alison Grinthal1, Rebecca Schulman1,2,3

  • 1Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA. rschulm3@jhu.edu.

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概括

科学家们开发了一个新的分析框架来控制合成生物学和软材料中的空间度场. 这个框架提供了精确的,可预测的梯度设计,没有复杂的模拟.

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科学领域:

  • 合成生物学 合成生物学
  • 材料科学 材料科学 材料科学
  • 生物物理学的生物物理.

背景情况:

  • 控制空间度场对于合成生物学和软材料至关重要.
  • 大自然使用形态梯度进行发育,但合成方法依赖于经验或基于模拟的方法.

研究的目的:

  • 介绍扩散降解系统中来自局部源的稳态度场的分析框架.
  • 为了获得1D,2D和3D几何学的闭式解决方案.
  • 为编程度范围制定定量设计策略.

主要方法:

  • 开发了扩散降解系统的分析框架.
  • 对于度场的衍生闭式溶液.
  • 使用泰勒模块,以无维形式表达解决方案.
  • 引入了一个基于值标准的设计策略.

主要成果:

  • 导出显示梯度度的无维解决方案取决于泰勒模量.
  • 确定了不同的设计模式:在降解主导的系统中,维度独立的指数衰减,在扩散主导的系统中,维度依赖的功率定律缩放.
  • 证明与数值解决方案和实验数据的一致性.

结论:

  • 该框架为设计稳定状态度场提供了一种可通用和物理透明的方法.
  • 能够对合成生物和软物质系统中的梯度介导组织进行预测控制.
  • 减少对梯度设计的计算密集型模拟的依赖.