儿科患有复发或耐火性肉瘤的儿科患者的gemcitabine-docetaxel治疗:单中心体验
Metin Çil1, Begül Ganiye Yağcı1
1Division of Pediatric Hematology and Oncology, Department of Pediatrics, Adana City Training and Research Hospital, Ministry of Health, Adana, Türkiye.
Frontiers in pediatrics
|February 11, 2026
概括
吉姆西塔宾和多塞塔克塞尔 (GEMDOX) 组合显示,在儿科复发性/耐火性肉瘤中具有可管理的安全性. 虽然反应率很低,但当治疗治疗方法有限时,它提供了息选择.
科学领域:
- 儿科瘤学 儿科瘤学
- 医学化疗 医学化疗
- 肉瘤治疗方法 治疗肉瘤
背景情况:
- 儿科肉瘤的预后很差,救援选择有限.
- 评估格姆西塔和多塞 (GEMDOX) 组合的疗效和毒性.
研究的目的:
- 评估GEMDOX在患有复发性或耐火性肉瘤的儿科患者的疗效和安全性.
- 确定反应率,生存结果和毒性概况.
主要方法:
- 对36名接受GEMDOX治疗的儿科患者进行了回顾性分析.
- 杰姆多克斯疗法: gemcitabine (1000 mg/m2第1天第8天) 和dcetaxel (100 mg/m2第8天第8天) 在21天周期中.
- 患者的平均年龄为13.5岁;骨肉瘤最常见 (58.3%).
主要成果:
- 目标反应率 (ORR) 为5.8%,疾病控制率 (DCR) 为14.6%.
- 无进展生存时间 (PFS) 中位数为5.72个月;总生存时间 (OS) 中位数为12.33个月.
- 最常见的3-4级毒性:中性质衰竭 (22.2%) 和发烧性中性质衰竭 (19.4%),可以通过G-CSF支持进行管理. 没有与治疗相关的死亡率.
结论:
- 在重度预治疗的儿科肉瘤患者中,GEMDOX具有可控的安全性.
- 当治疗选择有限时,它是一种可行的息选择,具有可控的毒性.
- 在复发环境中,可以在早期实现最佳疗效.
相关概念视频
Patient-centered Care
3.1K
Patient-centered care involves delivering care beyond inpatient hospitalization. Reflective practice can enhance a patient-centered approach. Reflective practice is a process of reasoning that considers all aspects of the present situation, including practicalities, learning from personal practice, and consideration of patient needs. Patients appreciate care decisions made while considering their input. Involving the patient in their care provides the patient with a sense of contribution rather...
3.1K
Pharmacokinetics in Pediatric Patients: Drug Excretion
277
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
277
Pharmacokinetics in Pediatric Patients: Drug Distribution
334
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
334
Pharmacokinetics in Pediatric Patients: Drug Metabolism
245
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
245
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
310
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
310
Lattice Centering and Coordination Number
12.2K
The structure of a crystalline solid, whether a metal or not, is best described by considering its simplest repeating unit, which is referred to as its unit cell. The unit cell consists of lattice points that represent the locations of atoms or ions. The entire structure then consists of this unit cell repeating in three dimensions. The three different types of unit cells present in the cubic lattice are illustrated in Figure 1.
Types of Unit Cells
Imagine taking a large number of identical...
Types of Unit Cells
Imagine taking a large number of identical...
12.2K


