在B细胞淋巴瘤经历了30多年的惰过程后,在每次复发时都有免疫表型变化
Shintaro Yamanaka1, Shinji Hasebe1, Tomomi Fujii2
1Cancer Center, Ehime University Hospital, Toon city, Japan.
European journal of case reports in internal medicine
|February 11, 2026
概括
扩散性大B细胞淋巴瘤 (DLBCL) 可以随着时间的推移改变其亚型,影响治疗. 重复活检对于准确的诊断和复发病例的个性化治疗至关重要.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 免疫型定型 免疫型定型
背景情况:
- 扩散性大B细胞淋巴瘤 (DLBCL) 是一种具有不同亚型的异质恶性瘤.
- 在DLBCL中,细胞起源特征 (COO) 在长期疾病过程中的稳定性尚未得到充分理解.
- 长期患者数据对于了解疾病演变至关重要.
研究的目的:
- 调查DLBCL在长时间内免疫类型和分子进化的潜力.
- 为了确定DLBCL的原始细胞概况在重复复发作和治疗过程中是否保持静态.
- 强调在复发时重新评估DLBCL特征的重要性.
主要方法:
- 一个患者病例研究,诊断为DLBCL,跨越了三十年 (1988-2019).
- 在患者的整个病程和多次复发期间,进行了连续的组织病理学和免疫类型评估.
- 记录了治疗史,包括各种化疗方案和向疗法.
主要成果:
- 该患者表现出DLBCL,其免疫类型从一个类似于B细胞的生殖中心 (GCB) 转变为类似于B细胞的激活型 (ABC) /非GCB模式.
- 这种疾病在晚期发展为CD30阳性形B细胞变体.
- 患者经历了多个治疗线,在31年内连续复发.
结论:
- 几十年来,DLBCL可以经历显著的逐步免疫表型和分子演变.
- DLBCL的COO概况不是静态的,并且可以在疾病过程中发生变化.
- 重复活检和全面的重新评估对于将治疗策略与复发性DLBCL的当前状况进行量身定制至关重要.
相关概念视频
01:07What are Cells?
204.9K
Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
204.9K
01:15What are Cells?
49.8K
Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium, or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
49.8K
02:03What is Cell Signaling?
131.1K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
131.1K
02:58Chemistry of the Cell
48.4K
The cell is chemically composed of water, organic molecules and inorganic ions.
Water
The polarity of the water molecule and its resulting hydrogen bonding makes water a unique substance with special properties that are intimately tied to the processes of life. Life originally evolved in an aqueous environment, and most of an organism’s cellular chemistry and metabolism occur inside the aqueous contents of the cell’s cytoplasm. Special properties of water are its high heat capacity...
Water
The polarity of the water molecule and its resulting hydrogen bonding makes water a unique substance with special properties that are intimately tied to the processes of life. Life originally evolved in an aqueous environment, and most of an organism’s cellular chemistry and metabolism occur inside the aqueous contents of the cell’s cytoplasm. Special properties of water are its high heat capacity...
48.4K
02:41Concentration Cells
25.9K
A concentration cell is a type of a voltaic cell constructed by connecting two almost identical half-cells, both based on the same half-reaction and using the same electrode, differing only in the concentration of one redox species. A concentration cell's potential, therefore, is determined only by the concentration difference of the particular redox species.
Consider the following voltaic cell:
Consider the following voltaic cell:
25.9K
01:22Cell Size
132.0K
Cell sizes vary widely among and within organisms. Bacterial cells range between 1-10 micrometers (μm)and are considerably smaller than most eukaryotic cells. The smallest bacteria are 0.1 μm in diameter—about a thousand times smaller than eukaryotic cells, which typically range from 10-100 μm.
Surface Area
Cells can take in nutrients and water via diffusion through the plasma membrane itself or through specific channels in the membrane. The area of the membrane surrounding...
Surface Area
Cells can take in nutrients and water via diffusion through the plasma membrane itself or through specific channels in the membrane. The area of the membrane surrounding...
132.0K