癌症微环境中的辐射诱导的变化 (综述)
Haiying Liu1, Xiaoping Zhu1, Zhenxing He2
1Medical College, Hexi University, Zhangye, Gansu 734000, P.R. China.
Medicine international
|February 11, 2026
概括
癌细胞中放射治疗耐药性与影响瘤微环境的代谢变化有关. 将放射治疗与代谢治疗相结合可能会提高癌症治疗的有效性.
科学领域:
- 在瘤学瘤学.
- 癌症新陈代谢 癌症新陈代谢
- 放射疗法是一种放射治疗.
背景情况:
- 放射治疗是癌症治疗的基石,但抗辐射性限制了它的有效性.
- 癌细胞在辐射后表现出代谢重编程,以增强生存和适应.
- 这些代谢变化影响瘤微环境,可能促进癌细胞的增殖.
研究的目的:
- 审查放射治疗后癌细胞的代谢重编程.
- 讨论瘤微环境辐射后的代谢特征.
- 介绍有关纳米限制影响癌症微环境和新陈代谢的新发现.
主要方法:
- 关于癌细胞代谢和放射治疗的文献综述.
- 对瘤微环境代谢变化研究的分析.
- 讨论关于纳米限制及其机制的新兴研究.
主要成果:
- 辐射暴露会导致癌细胞发生显著的代谢变化.
- 癌细胞中的代谢变化会影响瘤的微环境.
- 纳米限制呈现了一种影响癌症新陈代谢和信号的新机制.
结论:
- 针对性代谢干预与放射治疗相结合,有望改善癌症治疗.
- 了解辐射诱导的代谢重编程对于克服抵抗至关重要.
- 纳米限制策略为调节瘤微环境和改善治疗结果提供了新的途径.
相关概念视频
Biological Effects of Radiation
18.1K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
18.1K
Review and Preview
8.4K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview
11.6K
Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.6K
Alterations in Respiration II
1.9K
There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
1.9K
Altered States of Awareness
1.2K
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
1.2K
Mechanisms of Retrovirus-induced Cancers
7.0K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
7.0K


