消化系统癌症患者中自杀风险和死亡率:系统性审查和元分析
Yebin Wang1, Xiaotian Yang1, Mengyao Song2
1The First Clinical School of Medicine, Zhengzhou University, Zhengzhou, China.
Frontiers in oncology
|February 11, 2026
概括
与普通人群相比,消化道癌症患者面临的自杀风险是两倍以上. 这一元分析强调了高标准化死亡率 (SMRs),并呼吁加强对这些人的心理支持.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 癌症治疗的进步尚未完全解决消化道癌症患者的自杀风险.
- 关于消化系统癌症患者自杀率的现有研究存在争议,缺乏确定的风险因素.
研究的目的:
- 在消化系统癌症患者中对标准化死亡率 (SMR) 进行系统审查和元分析.
- 为了确定特定的风险因素,并量化这一群体的自杀风险.
主要方法:
- 在PubMed,Embase,Web of Science和Cochran图书馆数据库中进行系统搜索,截至2025年6月.
- 用随机效应模型对12项队列研究进行元分析,其中包括6,763,452名消化系统癌症患者.
- 根据癌症类型,性别,预后,诊断后的时间,地区和招募年份分层评估SMR;评估出版偏差.
主要成果:
- 消化系统癌症患者的总体SMR为2.25 (95% CI:1.89-2.66),表明与普通人群相比,自杀风险是两倍以上.
- 在食道 (3.35),胰腺 (3.87),胃 (2.10),肝 (1.89),结肠直肠 (1.57) 癌症中观察到显著增加的SMR.
- 根据癌症类型和其他影响因素,SMR显示出显著的差异.
结论:
- 消化系统癌症患者的自杀风险显著增加,是普通人群的两倍多.
- 在被诊断患有消化道癌症的个人中,加强心理支持对于管理自杀风险至关重要.
- 对特定风险因素的进一步研究是有必要的,以完善支持策略.
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