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综合单细胞和空间转录组学与全外体测序相结合,揭示了膀癌中关键的枢纽基因和上皮异质性

Lin Li1,2, Qianyue Li2, Jiaxin Liu1

  • 1Department of Medical College, Shihezi University, Shihezi, Xinjiang, China.

Frontiers in oncology
|February 11, 2026
PubMed
概括

这项研究确定了膀癌 (BLCA) 中的关键上皮细胞亚型,并发现ABRACL和ARPC3 是与瘤突变负担 (TMB) 相关的关键基因. 这些发现为改善BLCA诊断和治疗提供了潜力.

关键词:
膀癌:膀癌是一种癌症.与癌症相关的上皮细胞.一个单细胞RNA测序.空间转录学 空间转录学瘤微环境是一个微环境.瘤突变负担 瘤突变负担

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