提取物调节PI3K/AKT级联并抑制肺癌细胞系的增殖
Fereshteh Ramezani Zardanjani1, Hajar Yaghoobi2, Abbas Alibakhshi3
1Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Advanced biomedical research
|February 11, 2026
概括
阿尔哈吉毛罗伦提取物显示对非小细胞肺癌的抗癌作用. 这种天然化合物抑制PI3K/AKT通路,为肺癌治疗提供了潜力.
科学领域:
- 植物化学 植物化学
- 分子生物学分子生物学
- 在瘤学瘤学.
背景情况:
- 非小细胞肺癌 (NSCLC) 仍然是一个重大的健康问题.
- 研究天然化合物的抗癌性质对于新疗法开发至关重要.
研究的目的:
- 为了评估酒提取物*Alhagi maurorum*对NSCLC的抗癌作用.
- 为了识别肺癌细胞中受到*A. maurorum*影响的分子标和途径.
主要方法:
- 对NSCLC信号通路 (KEGG,EnrichR,STRING) 的生物信息分析.
- 对 *A. maurorum* 化合物的分子对接和动力学模拟对路径目标.
- 在A549肺癌细胞的体外抗氧化剂 (DPPH) 和细胞毒性 (MTT) 测定中.
- 与KEGG通路相关的基因表达分析实时PCR.
主要成果:
- PI3K-Akt信号通路被确定为NSCLC的一个关键通路.
- *A. maurorum* 提取物对A549细胞具有细胞毒性作用,IC50为277μg/ml.
- 提取物表现出抗氧化活性,并在PI3K/AKT通路内特别抑制PTEN.
结论:
- 酒精提取物*Alhagi maurorum*具有针对NSCLC的抗癌性质.
- 提取物的机制涉及PI3K/AKT信号通路的抑制,可能通过向PTEN.
- *A. maurorum* 是开发新型肺癌治疗药物的有希望的候选者.
更多相关视频
11:13Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
Published on: June 9, 2023
2.4K
13:18Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma
Published on: March 3, 2023
1.8K
相关概念视频
01:22PI3K/mTOR/AKT Signaling Pathway
5.7K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
5.7K
01:24Intracellular Signaling Cascades
53.7K
Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
53.7K
01:25Rab Cascades
3.6K
Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
3.6K
00:46Feedback Inhibition
57.3K
Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
57.3K
02:36Cells Coordinate Growth and Proliferation
5.1K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
5.1K
01:46Epigenetic Regulation
33.9K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.9K