案例报告:HER2阳性阴道帕杰特病通过基于trastuzumab的全身疗法加放射治疗实现长期控制
Xiaohui Xie1, Qinyang Chen2, Jian Zhang1
1West China School of Medicine, Sichuan University Affiliated Chengdu Second People's Hospital, Chengdu Second People's Hospital, Sichuan University, Chengdu, Sichuan, China.
Frontiers in medicine
|February 11, 2026
概括
这一案例研究突出了晚期阴道帕杰特病 (VPD) 的有希望的治疗方法. 化学疗法和放射治疗的HER2向治疗在无法手术的患者中实现了显著的瘤缩和持续的疾病控制.
科学领域:
- 在瘤学瘤学.
- 妇科瘤学 妇科瘤学
- 医学研究 医学研究
背景情况:
- 二次侵入性腺癌的 Vulvar Paget 病 (VPD) 存在重大管理挑战,特别是在不可手术或复发的病例中.
- 准确的诊断和有效的治疗策略对于改善患者的结果至关重要.
研究的目的:
- 报告一种罕见的HER2阳性侵袭性阴道巴杰特病病例.
- 为类似具有挑战性的病例分享诊断和治疗经验.
- 为管理不可操作或复发性VPD提供指导.
主要方法:
- 一名79岁的妇女患有大,HER2-阳性 (3+) 侵袭性阴道巴杰特病.
- 由于无法操作,患者接受了trastuzumab与capecitabine化疗相结合.
- 随后的复发和转移治疗包括相同的治疗方案加放射治疗.
主要成果:
- 开始使用trastuzumab和capecitabine治疗后,瘤显著缩小.
- 在复发和骨转移后,联合治疗和放射治疗导致部分缓解.
- 特拉斯图祖马布的维护已经维持了17个月的疾病控制.
结论:
- 针对HER2的治疗,化疗和放射疗法为HER2阳性,不可手术或复发性阴道帕杰特病提供了有希望的策略.
- 这种多式联络方法可以实现持久的疾病控制,并改善具有挑战性的病例的结果.
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