肥胖状况轨迹与糖尿病前血糖状况变化的关联
Salma Nabila1, Ji-Eun Kim2, JooYong Park3
1Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea.
Journal of cancer prevention
|February 11, 2026
概括
保持非肥胖状态与更好的糖尿病前期结果有关. 稳定不肥胖或变得不肥胖的人有较高的正常血糖率和患糖尿病的风险较低.
科学领域:
- 代谢健康 代谢健康
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 糖尿病前期影响人口的很大一部分,增加糖尿病的风险.
- 肥胖是糖尿病前期和其发展为2型糖尿病的主要危险因素.
- 了解肥胖的轨迹对于管理糖尿病前期至关重要.
研究的目的:
- 调查肥胖状况轨迹与糖尿病前期结果之间的关联.
- 为了确定是否保持或实现非肥胖状态会影响恢复到正常血糖或进展到糖尿病.
- 在糖尿病前期群体中识别明显的肥胖模式.
主要方法:
- 隐性类增长分析用于确定肥胖轨迹 (体重指数≥25 kg/m2).
- 因果特异性危险回归分析了肥胖轨迹和糖尿病前期结果 (恢复到正常血糖或进展为糖尿病) 之间的关联.
- 分析了国家健康保险服务-国家健康查队列 (2002-2016) 的14452名参与者的数据.
主要成果:
- 确定了三种肥胖轨迹:"稳定肥胖"",稳定非肥胖"和"肥胖至非肥胖".
- "稳定非肥胖"和"肥胖至非肥胖"组的参与者表现出明显更高的正常血糖逆转率 (HR分别为1.30和1.15).
- 与"稳定肥胖"组相比,这些组的糖尿病发病风险也较低 (HR分别为0.78和0.90).
结论:
- 保持或实现非肥胖状态与糖尿病前期患者的改善血糖控制有关.
- 针对肥胖的体重管理干预措施可能有效地预防糖尿病的进展.
- 纵向肥胖模式显著影响糖尿病前期的结果.
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