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氨酸摄入量,饮食中的酸负荷和乳腺癌风险:一项病例对照研究
Alvaro L Ronco1, Wilner Martínez-López2, Maximilian A Storz3
1Department of Medical Records, National Cancer Institute of Uruguay, Germany.
Journal of cancer prevention
|February 11, 2026
概括
饮食中含有高酸和的饮食可能会增加乳腺癌的风险. 氨基酸 metionin 可能在这种关联中发挥重要作用,可能是通过表观遗传机制.
科学领域:
- 在瘤学瘤学.
- 营养流行病学 营养流行病学
- 代谢生物化学 代谢生物化学
背景情况:
- 有限的证据将食中的酸量和氨酸摄入量与癌症风险联系起来.
- 酸性压力和代谢性酸性化与癌症的发展有关.
- 氨酸是一种关键的酸性氨基酸,具有潜在的表观遗传效应.
研究的目的:
- 为了研究饮食中的酸负荷,氨酸摄入量和乳腺癌风险之间的关联.
- 重新评估关于这些饮食因素和乳腺癌的初步发现.
- 探索家族病史和更年期状况的潜在修改影响.
主要方法:
- 一项涉及乌拉圭572例病例和2,294例对照的病例控制研究.
- 使用脏潜在酸负荷 (PRAL) 评分估计的食酸负荷.
- 逻辑回归用于计算赔率比率 (OR),调整为混因素.
主要成果:
- 在乳腺癌风险和PRAL (OR=3.33) 和 metionin摄入量 (OR=5.87) 之间发现了显著的直接联系.
- 对于PRAL和 metionin摄入量的趋势在统计学上是显著的 (P < 0.001).
- 在有癌症家族史的女性和绝经前妇女中,观察到PRAL和甲因的较高OR.
结论:
- 酸性饮食模式可能会增加乳腺癌的风险.
- 氨酸摄入量与乳腺癌风险有很强的关联,可能会调解酸不平衡的影响.
- 进一步研究 metionin 对癌症发展的表观遗传影响是有必要的.
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