中性粒细胞与淋巴细胞的比作为创伤性脊髓损伤不良结果的预测因素:系统性审查和元分析
Amirreza Peyrovinasab1, Hamed Zarei2, Mahrokh Janmohamadi3
1Men's Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Archives of academic emergency medicine
|February 11, 2026
概括
中性粒细胞与淋巴细胞的比率 (NLR) 与创伤性脊髓损伤 (SCI) 的较差结果有关. 升高的NLR表明损伤严重程度更高,并预测SCI患者的神经恢复较差.
科学领域:
- 神经科学是一个神经科学.
- 炎症研究 炎症研究
- 生物标志物发现发现
背景情况:
- 脊髓损伤 (SCI) 的结果受到炎症生物标志物的影响.
- 创伤性SCI中中性粒细胞与淋巴细胞比率 (NLR) 的预后值需要进一步调查.
研究的目的:
- 系统地审查并对创伤性SCI患者的NLR预后价值进行元分析.
- 评估基线NLR与创伤性SCI中神经改善或损伤严重程度之间的关联.
主要方法:
- 在Medline,Embase,Scopus和Web of Science数据库中进行系统搜索.
- 包括6个回顾性队列研究,1564名参与者;五项研究进行了元分析.
- 使用NHLBI工具评估偏差风险;用于元分析的随机效应模型.
主要成果:
- 分析显示,在没有神经改善的患者中,NLR值显著更高 (SMD:0.98;95% CI:0.08-1.87).
- 升高的NLR独立地与没有神经改善有关 (调整后OR:1.12;95%CI:1.06-1.17).
- 定性合成表明较高的NLR与急性创伤性SCI中较大的损伤严重程度相关.
结论:
- 升高的NLR与急性创伤性SCI的损伤严重程度增加和神经恢复减弱有关.
- 对于评估创伤性SCI患者来说,NLR可以作为一个有价值的早期预后生物标志物.
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