局部低肌肉质量与手部功能障碍有关,除了类风湿性关节炎的炎症之外:一个横截面研究
Ying Yang1, Yao-Wei Zou1, Ye Lu1
1Department of Rheumatology and Immunology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
PeerJ
|February 11, 2026
概括
类风湿性关节炎患者的较低的上肢肌肉质量经历更大的手部功能障碍. 这凸显了评估肌肉质量在RA护理中的重要性,以改善患者的治疗结果.
科学领域:
- 类风湿病学 类风湿病学
- 肌肉骨健康 肌肉骨健康
- 临床评估 临床评估
背景情况:
- 在类风湿性关节炎 (RA) 中,全身肌肉损失与身体功能障碍有关.
- 上肢肌肉恶化对RA患者手部残疾的具体影响尚不清楚.
研究的目的:
- 在风湿性关节炎 (RA) 患者中调查上肢肌肉质量低与手部功能障碍之间的关联.
主要方法:
- 一项涉及1,104名RA患者和3,281名对照者的横截面研究.
- 上肢肌肉质量指数 (MMIUE) 使用生物电阻分析进行测量.
- 手功能通过握力和斯坦福健康评估问卷-残疾指数 (HAQ-DI) 进行评估.
主要成果:
- 与对照组相比,RA患者的MMIUE显著降低,肌肉质量低的患病率更高.
- 在RA患者中,低MMIUE与较低的手握强度和更高的HAQ-DI手部残疾密切相关.
- 后勤回归证实,低MMIUE增加了RA患者手握强度低和手部残疾的风险.
结论:
- 在上肢的局部低肌肉质量是独立与手部功能障碍在类风湿性关节炎 (RA).
- 这些发现表明,例行肌肉质量评估可能有助于管理RA患者.
- 建议进行进一步的纵向研究,以探索肌肉质量评估在RA护理中的治疗影响.
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