在中国东部的Streptococcus suis的流行病学调查和致病性
Dehong Yang1,2, Jingyu Xu1,2, Meiling Hu1,2
1College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Frontiers in microbiology
|February 11, 2026
概括
瑞杆菌 (S. suis) 感染了中国东部近60%的猪,其中2型血清菌是最常见和高度毒性的. 这项研究突出了区域差异和关键的病毒性基因,用于对猪进行S. suis控制.
科学领域:
- 兽医微生物学 兽医微生物学
- 动物健康 动物健康
- 动物传播疾病 动物传播疾病
背景情况:
- 瑞士白杆菌 (S. suis) 是一种重要的动物性传染病原体,在猪和人类中引起败血症和肺炎.
- 有限的大规模流行病学数据存在于中国东部的猪群中S. suis.
研究的目的:
- 调查来自中国东部的S. suis分离物的血清型,毒性基因和病原性.
- 为有效预防和控制猪养殖场S. suis感染的战略提供数据.
主要方法:
- 从中国12个地区的89个养猪场收集了S. suis分离物 (2022-2024年).
- 通过动物挑战实验进行了血型鉴定,病毒性基因分析 (gdh,gapdh,orf2,mrp,gdh,89k,epf,sly) 和致病性测试.
主要成果:
- 总体而言,S. suis感染率为59.59%,广东省感染率最高 (72.41%).
- 血清型2是最常见的 (30.66%),特别是在广东,广西和安. 血清型7 (21.17%) 和9 (10.95%) 也很常见.
- 观察到gdh,gapdh和orf2基因 (>89%) 的高发生率. 血清型2分离物含有所有测试基因,而血清型7分离物缺乏89k和epf. 血清型9显示低SLI和EPF发生.
- 血清型2导致猪100%的死亡率,而血清型7导致37.5%的死亡率,症状较轻.
结论:
- 在中国东部,S. suis感染很普遍,具有显著的区域和季节性变化.
- 在沿海省份,血清型多样性正在增加. 血清型2具有较高的死亡风险,而血清型7的毒性较小.
- 了解血清型分布和毒性因子对于在猪群中针对性预防和控制S. suis至关重要.
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