进化中的抗VEGF安全性:对眼部和系统性考虑的全面审查
Ramesh Venkatesh1, Preksha Biradar1, Gaurav Malwe1
1Department of Vitreo-retinal Services, Narayana Nethralaya, Bangalore, Karnataka, India.
Indian journal of ophthalmology
|February 11, 2026
概括
内抗VEGF治疗对视网膜疾病有效,但可能导致眼内炎症 (IOI) 和全身事件. 了解药物特性,患者因素和免疫性是管理这些风险的关键.
科学领域:
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 静脉内抗VEGF治疗对视网膜血管疾病提供了显著的视觉益处.
- 长期治疗需要对眼睛和全身安全进行全面评估.
- 眼内炎症 (IOI) 是一个主要问题,从轻度到严重的血管炎.
研究的目的:
- 综合有关抗VEGF安全性的当前知识,重点关注IOI和系统性事件.
- 阐明影响不良事件的复杂相互作用,包括药物特性和患者因素.
- 提出一种针对抗VEGF治疗的风险分层和管理的框架.
主要方法:
- 审查当代临床数据和对抗VEGF相关不良事件的机制性见解.
- 分析导致眼内炎症 (IOI) 和全身并发症的因素.
- 开发一种风险评估和管理策略的易感性模型.
主要成果:
- IOI和系统性事件不是统一的药物效应,而是来自复杂的相互作用.
- 机制包括先天免疫激活 (急性无菌炎症) 和适应性免疫 (血管炎).
- 一个五支柱的易感性模型确定了不良事件的关键风险修饰因素.
结论:
- 个人风险评估和预防对于安全的抗VEGF治疗至关重要.
- 了解药物特异性,患者敏感性和免疫性优化治疗结果.
- 一种平衡的,以预防为重点的方法可以保持治疗效益,同时确保长期的安全性.
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