在常规实践中实施系统的早期协议活检:一个探索性的现实世界研究
Ana Rita Ramos1, Andreia Carnevale2, José Soares3
1Unidade local de Saúde do Médio Tejo, Nephrology department, Hospital de Torres Novas, Portugal
概括
协议活检可以早期检测亚临床移植排斥,从而允许干预. 排放时估计的更高的膜过率 (eGFR) 预测了更好的长期移植存活率.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 移植手术 移植手术
- 免疫学 免疫学 免疫学
背景情况:
- 急性排斥是对移植的主要威胁 长期的移植存活.
- 亚临床排斥通常在没有组织学评估的情况下无法检测到,从而导致渐进的移植损伤.
- 早期检测和干预对于保持移植功能至关重要.
研究的目的:
- 评估协议活检在检测亚临床排斥中的作用.
- 评估早期干预对移植功能的影响.
- 检查早期组织学发现的预后意义和排放估计的膜过率 (eGFR).
主要方法:
- 移植接受者的回顾性,单中心研究.
- 从早期协议活检中分析临床,免疫学和组织病理学数据.
- 评估班夫炎症评分,功能 (eGFR) 和长期结果.
主要成果:
- 在20.2%的患者中检测到排斥,主要是T细胞介导的.
- 早期干预显著改善了功能 (平均EGFR从36.0增加到51.0毫升/分钟/1.73米2).
- 较高的EGFR排放与更好的长期功能有很强的关联.
结论:
- 协议活检对于早期检测亚临床排斥至关重要,有助于及时干预.
- 排泄EGFR是长期移植结果的强有力的预测指标.
- 快速管理排斥可以改善移植的生存.
相关概念视频
Nursing Implementation
6.2K
Implementation is the execution of the nursing care plan developed during the planning phase.
The five steps to implementing effective nursing care include reassessing the patient, reviewing and revising the existing nursing care plan, organizing the resources and care delivery, anticipating and preventing complications, and implementing nursing interventions.
The five steps to implementing effective nursing care include reassessing the patient, reviewing and revising the existing nursing care plan, organizing the resources and care delivery, anticipating and preventing complications, and implementing nursing interventions.
6.2K
Random and Systematic Errors
15.2K
Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
15.2K
Systematic Sampling Method
13.4K
Sampling is a technique to select a portion (or subset) of the larger population and study that portion (the sample) to gain information about the population. Data are the result of sampling from a population. The sampling method ensures that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
Systematic sampling is one of the simplest methods...
Systematic sampling is one of the simplest methods...
13.4K
Propagation of Uncertainty from Systematic Error
1.5K
The atomic mass of an element varies due to the relative ratio of its isotopes. A sample's relative proportion of oxygen isotopes influences its average atomic mass. For instance, if we were to measure the atomic mass of oxygen from a sample, the mass would be a weighted average of the isotopic masses of oxygen in that sample. Since a single sample is not likely to perfectly reflect the true atomic mass of oxygen for all the molecules of oxygen on Earth, the mass we obtain from this...
1.5K
Characteristics of Practical Op Amps
872
A difference amplifier, a crucial component in numerous electronic devices, ideally amplifies only the difference-mode signal, which is the difference between two input signals. However, in practical circuits, the output voltage depends on both the differential gain and the common-mode gain.
The ratio of differential gain to the common-mode gain is defined as the common-mode rejection ratio (CMRR). This ratio quantifies the ability of operational amplifiers (op-amps) to reject common-mode...
The ratio of differential gain to the common-mode gain is defined as the common-mode rejection ratio (CMRR). This ratio quantifies the ability of operational amplifiers (op-amps) to reject common-mode...
872
Theoretical Foundations of Nursing Practice
17.7K
Theories play an essential role in organizing patient care. Theories refer to a proposed or followed belief, policy, or procedure that is the basis for action. Nursing theories are knowledge-based concepts that guide nurses' actions, influence nursing education and practice, and allow nurses to care for their patients.
Theories provide a perspective to assess patients' conditions and organize data and methods. They also assist in analyzing and interpreting information. They represent a...
Theories provide a perspective to assess patients' conditions and organize data and methods. They also assist in analyzing and interpreting information. They represent a...
17.7K


