用铁校正的MRI预测MASH活动的严重程度可预测2型糖尿病患者的胰岛素抵抗和心脏代谢风险
Andrea Ortiz Rocha1, Srilaxmi Kalavalapalli1, Eddison Godinez Leiva1
1Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Florida at Gainesville, FL, United States.
The Journal of clinical endocrinology and metabolism
|February 11, 2026
概括
在2型糖尿病患者中,通过铁校正的T1映射 (cT1) 测量的晚期肝病活性 (MASH) 与代谢风险因素相关. 这表明cT1可以帮助识别需要早期干预的个人,以代谢功能障碍相关的脂肪性肝病.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是2型糖尿病 (T2D) 的一个日益关注的问题.
- 随着纤维化和肝硬化进展为脂肪肝炎,T2D患者的发病率增加.
- 用铁校正的T1映射 (cT1) 显示了识别和分层MASH风险的潜力.
研究的目的:
- 研究cT1测量的MASH活性与T2D中的心脏代谢风险因素之间的关联.
- 探索cT1是否可以根据肝脏疾病活动和代谢健康来分层MASH风险.
主要方法:
- 109名T2D参与者根据cT1和肝脏脂肪含量分为四组.
- 测量包括胰岛素抵抗 (HOMA-IR),脂肪组织功能障碍 (Adipo-IR,阿迪波内克丁) 和非侵入性MASH/纤维化标志物 (NIS2+®,CK-18,FAST,MRE).
主要成果:
- 较高的MASH活性 (cT1) 与增加的胰岛素抵抗和脂肪组织功能障碍相关 (p<0.01).
- 升高的cT1与更严重的肝脏死亡炎症和纤维化有关 (p<0.001).
- 更糟糕的MASH疾病活动与更严重的代谢综合征特征有关.
结论:
- 在T2D患者中,CT1评估的MASH活性与导致肝病的不良心脏代谢风险因素有关.
- cT1可能有助于早期识别高风险T2D个体,以便及时介入初级保健.
- cT1为T2D肝病风险分层提供了一个潜在的工具.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
5.1K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.1K
Insulin Formulations: Types and Delivery
794
Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...
Short-acting insulins are divided into...
794
Predicting Products: SN1 vs. SN2
17.4K
Nucleophilic substitution reactions of alkyl halides can proceed via an SN1 or an SN2 mechanism. While in SN2 reactions, the nucleophile attacks the substrate simultaneously as the leaving group departs, in SN1 reactions, the substrate first dissociates to give the carbocation intermediate. Various factors such as the structure of the substrate, the strength of the nucleophile, and the nature of the solvent promote one mechanism over the other.
With increased substitution on the alkyl halide,...
With increased substitution on the alkyl halide,...
17.4K
Diabetes Mellitus: Overview and Type I Subtype
5.5K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.5K
Distance Corrections
301
To achieve precise distance measurements, especially in surveying and construction, certain corrections must be applied to account for potential sources of error like the standardization errors, temperature variations, and slope adjustments.Standardization error emerges when measurement equipment undergoes changes, such as wear, repairs, or weather impacts. To address this, surveyors compare the equipment’s readings to a standard. This process identifies any deviation that might lead to...
301
Power Factor Correction
557
The power transmission to a factory involves the transfer of apparent power, a combination of active and reactive power. The power factor measures how effectively electrical power is converted into useful work output. The ratio of the real power (KW) that does the work to the apparent power (KVA) supplied to the circuit.
557


