抗精神病治疗模式和心脏代谢药物的使用:现有现实世界的证据
Ramya Padmavathy Radha Krishnan1, Helga Zoega2, Nicholas A Buckley1
1Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Epidemiology and psychiatric sciences
|February 11, 2026
概括
抗精神病药物使用者的心脏代谢药物使用率较高,与剂量,持续时间和多种药物有关. 持续使用低剂量的抗精神病药物也增加了心脏代谢药物的患病率,需要监测.
科学领域:
- 药物监督 药物监督 药物监督
- 心血管健康 心血管健康
- 心理健康治疗 心理健康治疗
背景情况:
- 越来越多的非标签抗精神病药物使用,通常是低剂量,引发了对心脏代谢健康的担忧.
- 了解抗精神病治疗模式及其对心脏代谢结果的影响对于预防长期健康问题至关重要.
研究的目的:
- 调查抗精神病药物使用者与非使用者之间使用心脏代谢药物的患病率.
- 检查抗精神病治疗模式 (剂量,持续时间,多药) 与心脏代谢药物使用之间的关联.
- 为了识别常见的抗精神病-心脏代谢共处置模式.
主要方法:
- 澳大利亚国家药品发行索赔数据的回顾性分析 (2022年).
- 包括年龄在15-64岁之间,抗精神病药物分发≥2次的个体.
- 普森回归用于计算心脏代谢药物使用的调整流行率 (aPR);无监督的等级聚类用于共处置模式.
主要成果:
- 抗精神病药物使用者的心脏代谢药物患病率 (35.8%) 比非使用者 (26%) 高,aPR=1.30.
- 在年轻的成年人 (20-49岁) 和女性中观察到抗糖尿病药物,脂质修饰剂和抗高血压药物的使用增加.
- 心脏代谢药物的使用与更高的抗精神病剂量,更长的治疗持续时间和多药性相关;持续低剂量使用特定抗精神病药物也显示出高患病率.
结论:
- 长期的抗精神病治疗与心脏代谢药物的使用增加有关.
- 对服用抗精神病药物的患者来说,积极监测不良心脏代谢效应是必不可少的.
- 考虑戒除抗精神病药物或及时干预对于减轻发病率至关重要.
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