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相关概念视频

What is the Immune System?01:38

What is the Immune System?

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Overview
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Lung Capacity01:47

Lung Capacity

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The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
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Cell-mediated Immune Responses01:40

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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Humoral Immune Responses01:36

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Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

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The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
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Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines
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T细胞免疫力和肺癌的作用

Kotaro Yamada1, Yosuke Togashi1,2,3

  • 1Department of Respiratory Medicine, Okayama University Hospital, Okayama, Japan.

Respirology (Carlton, Vic.)
|February 11, 2026
PubMed
概括

T细胞对于肺癌免疫力和免疫疗法的有效性至关重要. 了解T细胞耗尽,调节和瘤微环境是改善治疗和患者结果的关键.

科学领域:

  • 免疫学 免疫学 免疫学
  • 在瘤学瘤学.
  • 癌症研究 癌症研究

背景情况:

  • 肺癌是全球主要的健康问题,治疗选择有限.
  • 免疫检查点抑制剂 (ICI) 已经推进了肺癌治疗,但也有局限性.
  • T细胞在抗瘤免疫和对ICI的反应中发挥着核心作用.

研究的目的:

  • 审查T细胞在肺癌中的多方面的作用.
  • 总结一下了解T细胞介导抗瘤免疫的最新进展.
  • 探索影响T细胞功能和治疗疗效的因素.

主要方法:

  • 关于T细胞在肺癌中的作用的文献综述.
  • 分析T细胞子集 (CD8+,调节性T细胞) 和它们的功能.
  • 检查三级淋巴体结构 (TLS) 和瘤微环境 (TME) 的影响.

主要成果:

  • 瘤特异性CD8+ T细胞至关重要,但可以耗尽.
  • 调节性T细胞抑制抗瘤反应,影响结果.
  • TLS可以增强局部免疫力,与更好的预后和治疗反应相关.
  • 瘤微环境的新陈代谢影响T细胞的持久性和分化.
关键词:
在T毛囊辅助细胞中.T细胞耗尽的情况在T淋巴细胞中,有细胞毒性.调控T淋巴细胞的监管作用免疫检查点抑制剂 免疫检查点抑制剂肺部瘤是什么 肺部瘤瘤微环境是一个微环境.

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结论:

  • 优化免疫疗法需要深入了解T细胞功能状态.
  • 准T细胞调节回路可以提高治疗效率.
  • 对肺癌T细胞生物学进行进一步的研究对于持久的临床益处至关重要.