炎症性肠病中的肝纤维化和肥胖症:一个交叉截面匹配控制的过渡弹性图形学研究 (ELASTIBD)
Besim Fazil Agargun1, Ibrahim Volkan Senkal1, Aynura Rustamzada1
1Istanbul Faculty of Medicine- Istanbul University, Division of Gastroenterohepatology- Department of Internal Medicine, Istanbul, Turkey.
概括
与对照组相比,患有炎症性肠病 (IBD) 的患者肝纤维化和胆固醇症的发病率明显更高. 抗TNF治疗可能会降低纤维化风险,而皮质类固醇与IBD患者的概率增加有关.
科学领域:
- 胃肠病学和肝病学
- 炎症性肠病 (IBD) 研究研究
- 肝病流行病学 肝病流行病学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 和肝纤维化越来越多地被认为是炎症性肠病 (IBD) 的肠外表现.
- 这些肝病的确切患病率和IBD治疗对肝脏健康的影响需要进一步调查.
研究的目的:
- 与匹配的对照组相比,确定IBD患者肝硬化和纤维化患病率.
- 调查IBD疗法,特别是抗TNF药物和皮质类固醇,以及肝纤维化和胆固醇病的存在之间的关联.
主要方法:
- 一项涉及358名患有IBD的成年人和358名单独匹配的对照者的横截面研究.
- 使用振动控制的短暂弹性图 (VCTE;FibroScan) 来评估肝硬化和纤维化.
- 分析了正在进行的ELASTIBD队列的基线数据.
主要成果:
- 与对照组相比,IBD患者的显著纤维化率 (12.3%与4.2%) 和肥胖症 (41.4%与28.3%) 显著增加.
- 抗TNF治疗与纤维化几率降低有关 (aOR 0.39),而皮质类固醇使用增加了纤维化几率 (aOR 1.41).
- 年龄较大和BMI较高被确定为肝纤维化的额外预测因素.
结论:
- 与对照组相比,IBD患者的纤维化增加了三倍,脂肪酸增加了两倍,这凸显了IBD护理中肝脏评估的必要性.
- 抗TNF治疗和纤维化之间的反向关系表明,控制炎症可能会减轻肝脏纤维化.
- 需要对ELASTIBD队列进行进一步的随访,以阐明疾病进展和治疗对肝脏结果的影响.
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