在西班牙裔和拉丁裔美国人队列中,大脑微型出血的患病率和与血管风险因素的关联
Vladimir Ivanovic1, Elmira Agah1, Stephan Seiler1
1Department of Neurology University of California Davis School of Medicine Sacramento CA USA.
Journal of the American Heart Association
|February 11, 2026
概括
高血管风险和中风病史与西班牙裔和拉丁裔成年人的大脑微型血液 (CMB) 有关. 认知障碍也增加了CMB的可能性,特别是在大脑深层区域.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 公共卫生 公共卫生
背景情况:
- 大脑微出血 (CMB) 是大脑中的小血管病变.
- 它们在像西班牙裔和拉丁裔个人这样的不同人群中的流行和关联需要进一步调查.
- 了解CMB对于评估脑血管健康和认知衰退至关重要.
研究的目的:
- 估计在多样化的西班牙裔和拉丁裔群体中CMB的流行率和数量.
- 研究CMB与人口统计因素,血管风险,APOE基因型和认知功能之间的关联.
主要方法:
- 使用来自SOL-INCA-MRI研究的3T脑磁共振成像 (MRI).
- 将CMB量化和分类为叶状,深层和混合位置.
- 检查了与年龄,性别,教育,心血管风险因素,APOE基因型和认知状态的关联.
主要成果:
- 在2455名参与者中,CMB患病率为11.7% (平均年龄为63.0岁,女性为67.9%).
- 高的弗雷明汉风险评分与CMB存在相关 (除了只有叶片).
- 认知障碍与混合CMB的更高患病率和总CMB数量的增加有关.
结论:
- 较高的血管风险得分和中风/过渡性缺血性发作史与CMBs的可能性增加有关.
- 认知状态与较高的CMB患病率显著相关,特别是在大脑深层区域.
- 研究结果强调了血管健康和认知功能的重要性,与该队列中的CMB有关.
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