赫斯佩雷丁在缓解糖尿病病中的机制:网络药理学,分子对接和实验验证
Yiwen Guo1, Fengjiao Zhang1, Yu Jin2
1Department of Endocrinology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China.
Journal of diabetes investigation
|February 11, 2026
概括
赫斯佩雷丁是一种天然化合物,通过改善细胞健康,减少炎症和铁亡,保护糖尿病病 (DN). 它通过调节胰岛素样生长因子1受体 (IGF1R) 来实现这一目标.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
- 细胞生物学 细胞生物学
背景情况:
- 糖尿病病 (DN) 是慢性病的主要原因.
- 了解hesperetin在DN中的作用对于治疗开发至关重要.
研究的目的:
- 为了研究hesperetin在糖尿病病中的调节机制.
- 探索hesperetin对细胞过程的影响,并确定其在DNA中的分子标.
主要方法:
- 使用高葡萄糖治疗的HK-2细胞和链毒素诱导的糖尿病小鼠作为DN模型.
- 评估了细胞活力,细胞亡,炎症性细胞因子,MDA,Fe2+和ROS水平.
- 使用网络药理学和分子对接来识别hesperetin的标IGF1R.
主要成果:
- 赫斯佩雷丁增强了细胞活力,减少了HG诱导的HK-2细胞中的细胞亡,炎症,MDA,Fe2+和ROS.
- 赫斯佩雷丁对IGF1R表现出高亲和度的结合,这种结合在受HG治疗的细胞中被上调.
- 沉默IGF1R赋予了保护,而其过度表达逆转了hesperetin的好处,表明其在hesperetin作用中的作用.
结论:
- 赫斯佩雷丁通过改善细胞活力和减少细胞亡,炎症和铁亡来缓解DN进展.
- 赫斯佩雷丁的保护作用部分通过调节细胞中的IGF1R表达来调节.
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