一个单一中心的研究:体外脂血对凝血试验的影响
Melek Karasu1, Aysegul Ozgenc, Dildar Konukoglu
1Istanbul University, Cerrahpasa, Cerrahpaşa Medical Faculty, Medical Biochemistry Department, İstanbul, Türkiye.
概括
脂血症显著影响凝血测试,如PT和纤维素生成. 确定特定的脂血指数 (LI) 截止值对于临床诊断的准确结果至关重要,特别是在紧急情况下.
科学领域:
- 临床化学 临床化学
- 血液学 血液学 血液学
- 实验室医学 实验室医学
背景情况:
- 凝血测试 (PT,aPTT,纤维素,INR,D-二次体) 对于管理抗凝血药物治疗和诊断血液疾病至关重要.
- 血脂症,以血脂升高为特征,是常见的预分析干扰,影响这些重要测试的准确性.
- 经常在急诊室收集的非禁食样本增加了脂血病的风险,可能会损害诊断可靠性.
研究的目的:
- 调查脂血病对关键凝血试验结果的影响.
- 为了确定显著干扰的脂血指数 (LI) 的特定切断值.
- 提高临床环境中凝血测试的诊断准确性,特别是在存在脂血症的情况下.
主要方法:
- 将脂质乳液的连续稀释添加到患者的血样本中.
- 使用Sysmex CS2500分析仪测量了凝血参数 (PT,aPTT,纤维素素,D-二次体).
- 测量了甘油三 (TG) 度和脂血指数 (LI),并计算偏差以确定LI截止值.
主要成果:
- 前列腺血时间 (PT) 和纤维素原水平受到高甘油 (TG) 度的影响.
- 激活的部分血栓形成时间 (aPTT) 对较低的TG度表现出敏感性.
- 已确定的LI截止值为PT的300,aPTT的50,纤维素的150和D-二次体的1200.
结论:
- 特定的脂血指数 (LI) 截止值对于准确解释凝血试验至关重要.
- 实验室应根据分析系统建立和验证自己的LI截止值.
- 考虑到脂血症的影响对于可靠的凝血测试至关重要,特别是在紧急医疗和患有失脂血症的患者中.
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