评估Cyproheptadine对急性神经乱药诱导的阿卡西西亚的有效性:双盲随机对照试验
Narges Shams-Alizadeh1, Azad Maroufi1, Khaled Rahmani2
1Department of Psychiatry, Neuropsychological Research Center, Kurdistan University of Medical Sciences.
Journal of clinical psychopharmacology
|February 11, 2026
概括
赛普罗赫巴丁有效治疗抗精神病药物诱导的阿卡西西亚,显著减少了痛苦和客观措施等症状. 这种药物显示出作为管理这种常见副作用的替代方案的承诺.
科学领域:
- 精神病学是一个精神病学.
- 临床药理学 临床药理学
- 神经科学是一个神经科学.
背景情况:
- 阿卡西西亚是抗精神病药物的常见和令人痛苦的副作用.
- 它会对患者的坚持和治疗结果产生负面影响.
- 评估神经乱药引起的阿卡西西亚的有效治疗方法至关重要.
研究的目的:
- 评估赛普罗赫普塔丁与安慰剂在治疗急性神经乱药诱导的阿卡西西亚方面的疗效.
- 用巴恩斯阿卡西西亚评分表 (BARS) 来量化阿卡西西亚症状的减少.
主要方法:
- 进行了一项双盲随机对照试验,50名精神病医院住院患者被诊断患有神经乱药诱导的阿卡西西亚.
- 参与者接受了cyproheptadine (4毫克每12小时) 或安慰剂.
- 在基线和干预后的第4天和第7天,使用BARS测量了阿卡西西亚症状.
主要成果:
- 与安慰剂相比,在第4天和第7天 (P<0.001) 赛普罗赫巴丁显著降低了BARS得分.
- 在全球性,痛苦,客观和主观的阿卡西西亚症状 (P<0.05) 中注意到了显著的改善.
- 治疗所需人数 (NNT) 约为2名患者,绝对风险降低 (ARR) 为0.52.
结论:
- 赛普罗赫巴丁在减少抗精神病药物诱导的阿卡西西亚症状方面表现出显著的有效性.
- 它呈现出一种潜在的替代治疗阿卡西西亚,与其他药物相比,具有有利的疗效.
- 昏昏欲睡是一个值得注意的副作用,但赛普罗赫普塔丁在两组之间食欲增加方面没有显著差异.
相关概念视频
02:07Blind Procedures
13.7K
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
13.7K
01:11Blinding
4.0K
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
4.0K
01:12Trial and Error and Algorithm
429
A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
429
01:11Clinical Trials: Overview
5.0K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.0K
01:16Clinical Trials
10.9K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
10.9K
01:04Random Error
9.8K
Random or indeterminate errors originate from various uncontrollable variables, such as variations in environmental conditions, instrument imperfections, or the inherent variability of the phenomena being measured. Usually, these errors cannot be predicted, estimated, or characterized because their direction and magnitude often vary in magnitude and direction even during consecutive measurements. As a result, they are difficult to eliminate. However, the aggregate effect of these errors can be...
9.8K