儿童群体的头骨底部手术-第二次国际合作研究 (1995-2015)
Dan M Fliss1, Omer J Ungar2,3, Helena Levyn4
1Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Head & neck
|February 11, 2026
概括
这项关于儿科头骨基底瘤的全球审查发现肉瘤是最常见的. 负边缘和辅助放射治疗改善了生存率,而持续的入侵恶化了结果.
科学领域:
- 儿科瘤学 儿科瘤学
- 神经外科 神经外科
- 头骨底部瘤 头骨底部瘤
背景情况:
- 全球对儿童恶性头骨底部瘤的综述.
- 来自28个机构的3061名患者的数据,包括64例儿科病例 (2.1%).
研究的目的:
- 审查儿科头骨底部恶性瘤的管理和结果.
- 确定影响这一群体生存的因素.
主要方法:
- 临床变量和生存结果 (OS和DFS) 的回顾性分析.
- 多变量分析以确定预后因素.
- 对外科手术方法的评估,包括开放式,内镜和组合技术.
主要成果:
- 瘤是最常见的恶性瘤 (57.8%),其次是静脉神经母细胞瘤 (25.0%) 和癌细胞瘤 (17.2%).
- 达到负的外科手术利与更好的结果相关 (53.1%的病例).
- 持续侵袭与总生存率 (OS) 和无病生存率 (DFS) 的降低相关;辅助放射治疗改善了生存率.
结论:
- 开放的外科手术方法普遍存在,但截至2015年,内镜技术增加.
- 结果反映了一个过渡时期,在儿科瘤学中扩大了内镜骨底部手术的使用.
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