甘 bagasse arabinoxylan通过调节肠道微生物群在小鼠中缓解硫酸诱导的大肠炎
Chunhua Chen1, Qixing Nie1, Yuyang Zhong1
1State Key Laboratory of Food Science and Resources, China-Canada Joint Lab of Food Science and Technology, Key Laboratory of Bioactive Polysaccharides of Jiangxi Province, Nanchang University, Nanchang 330047, China. spnie@ncu.edu.cn.
Food & function
|February 11, 2026
概括
甘巴加斯阿拉比诺西兰 (BGAX) 通过改善肠道健康并恢复有益的肠道细菌,有效治疗炎症性肠道疾病. 这种食纤维在治疗性结肠炎方面表现有前途.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 炎症性肠病 (IBD) 是一个重大的健康挑战.
- 阿拉比诺西兰是一种食纤维,对IBD有潜在的治疗益处.
研究的目的:
- 为了研究甘巴加斯阿拉比诺基兰 (BGAX) 对硫酸 (DSS) 诱导的大肠炎的保护作用.
- 在大肠炎模型中探索BGAX对肠道微生物群组成的影响.
主要方法:
- 在小鼠中诱导大肠炎使用硫酸 (DSS).
- 在接受治疗的小鼠中使用甘巴加斯阿拉比诺基兰 (BGAX).
- 评估临床症状,结肠组织学,炎症标志物和肠道微生物群组成.
主要成果:
- 在DSS诱导的大肠炎小鼠中,BGAX显著改善了体重,疾病活动指数 (DAI) 和结肠长度.
- BGAX恢复了结肠结构和杯状细胞数量,减少了炎症.
- BGAX调节肠道微生物群,增加有益的属 (例如,Roseburia,Akkermansia) 和减少有害的属 (例如,Clostridium,Enterococcus).
结论:
- 甘巴加斯阿拉比诺xylan (BGAX) 显示出对DSS诱导的大肠炎具有显著的保护作用.
- BGAX积极影响肠道微生物群组成,为IBD提供了潜在的治疗策略.
- 这些发现支持BGAX在性结肠炎患者的饮食管理中使用.
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