定制结肠直肠癌风险评估通过比较模型性能和定制值在一个占主导地位的西班牙裔队列
Jennifer C Molokwu1, Alok K Dwivedi2, Jonathan D Wing1
1Texas Tech University Health Sciences Center El Paso, Texas United States.
Cancer prevention research (Philadelphia, Pa.)
|February 11, 2026
概括
这项研究使用四种模型评估了西班牙裔人口的结肠直肠癌 (CRC) 风险. 弗里德曼是一个自由人.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 结肠直肠癌 (CRC) 是一个重大的公共卫生挑战,特别是在服务不足的社区.
- 沿美墨边境的西班牙裔人口面临着独特的健康差异.
- 准确的风险评估对于有效的CRC查和预防策略至关重要.
研究的目的:
- 为了评估在以西班牙裔为主群体中的结肠直肠癌 (CRC) 风险因素.
- 为了比较四种不同的CRC风险评估模型 (Freedman, Wells, Kaminski, Yeoh) 的性能.
- 确定这个特定人群中风险分层的最实用和最有效的模型.
主要方法:
- 分析了4202名CRC查参与者的数据,主要是西班牙裔女性.
- 使用弗里德曼,威尔斯,卡明斯基和Yeoh模型评估CRC风险.
- 检查模型一致性,风险分布和性别特异性风险趋势.
主要成果:
- 弗里德曼的模型表明,41.1%的参与者有超过平均寿命的CRC风险.
- 男性的终身风险较高 (51.3%),女性的10年风险较高 (26.3%).
- 弗里德曼和威尔斯的模型显示出强烈的一致性 (CCC = 0.76);卡明斯基和Yeoh确定了更多的高风险个体.
结论:
- 弗里德曼模型是这种西班牙裔群体中CRC风险评估的实用工具,提供了终身和10年估计.
- 量身定制的风险模型和定制值可以改善风险分层,以加强查和预防.
- 吸烟,肥胖和家族病史是CRC的关键风险因素,性别有所不同.
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