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卡斯帕斯-3指导的纳米感应器拆解用于实时NIR-II反瘤声动疗法的反

Chonglu Li¹, Shu Tian², Yuling Xu³

¹Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Sponsored by the Healthy Hubei Development and Social Progress Research Center of the Key Research Base of Humanities and Social Sciences in Hubei Province, School of Public Health, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China.

Analytical chemistry

|February 11, 2026

概括

这项研究介绍了一种用于声动疗 (SDT) 的新型纳米声敏剂,该疗法可以自行评估其有效性. 该系统使用近红外II光来实时提供关于瘤治疗疗效的反,从而实现精确的监测.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

声动力疗法 (SDT) 对深层瘤有希望,但缺乏实时有效性评估.
在分子水平上监测治疗反应对于优化癌症治疗至关重要.

研究的目的:

开发一种自我评估的纳米传感器,用于实时监测SDT的有效性.
将治疗交付和疗效反集成到一个单一的治疗平台中.

主要方法:

基于dketopyrrolopyrrole (DPP) 的声敏剂的合理分子设计,导致DPP5与NIR-II发射和ROS生成.
用一种可切割的caspase-3来使DPP5功能化,以形成光灭纳米粒子 (DPP5-CBTNP).
使用超声波 (US) 激活ROS生成并通过caspase-3触发纳米粒子分解,导致NIR-II光恢复.

主要成果:

DPP5-CBT NPs在美国辐射后表现出高效的ROS生成,诱导瘤细胞亡.
在亡过程中,酶-3的激活导致了纳米粒子分解,并显著增加了NIR-II光.
在caspase-3激活,SDT疗效和光恢复之间建立了直接的相关性.

结论:

开发的caspase-3响应纳米敏感剂可实现SDT治疗结果的非侵入性,实时自我评估.
这种综合治疗和反的治疗平台为精确和智能癌症治疗提供了一个新的范式.
分子工程方法对推进精确瘤学和治疗学有前途.

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