视网膜色素炎患者肠道微生物群多样性的增加以及对疾病表型和进展的含义
Tomoko Hasegawa1,2, Sachiko Iwai1, Hanako Ohashi Ikeda1,3
1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Investigative ophthalmology & visual science
|February 11, 2026
概括
视网膜色素炎 (RP) 患者表现出改变的肠道细菌. 在RP小鼠中,抗生素治疗通过减少炎症改善了视网膜健康,这表明肠道微生物群调节是RP的潜在治疗方法.
科学领域:
- 眼科医生 眼科 眼科
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 炎症是视网膜色素炎 (RP) 的常见特征,影响视觉结果.
- 肠道微生物群显著影响体内的炎症过程.
研究的目的:
- 调查肠道微生物群组成和视网膜色素炎之间的关联.
- 探索调节RP中的肠道微生物群的治疗潜力.
主要方法:
- 来自103名RP患者和64名健康对照的便样本的16S rRNA基因测序.
- 肠道微生物群多样性和群体之间的丰富性比较,包括带有或没有囊性黄斑 (CME) 的RP患者.
- 用抗生素治疗RP模型小鼠视网膜结构和功能的评估.
主要成果:
- 与健康个体相比,RP患者的肠道微生物群多样性明显高.
- 患有CME的RP患者表现出更大的多样性和特定细菌 (Romboutsia,Ruminococcus) 的丰富性.
- 在RP小鼠中,抗生素治疗保留了视网膜功能,减少了光受体损失,抑制了亡,并降低了NLRP3炎症酶通路组件的调节.
结论:
- 与健康个体相比,在RP患者中观察到不同的肠道微生物群概况.
- 在RP小鼠模型中,抗生素的使用减轻了疾病的进展.
- 准肠道微生物群是对视网膜炎的有希望的治疗途径.
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