在自闭症谱系障碍中使用leucovorin的临床问题和考虑
Caroline Howard1,2, Joseph Mekhail1,2, Lillian Maidman Ravikoff1,2
1Northwell.
Current opinion in pediatrics
|February 11, 2026
概括
莱可沃林可能有助于一些患有自闭症谱系障碍 (ASD) 的儿童,这些儿童患有脑叶酸缺乏症 (CFD). 然而,证据是混合的,美国儿科学会目前不建议在ASD中使用它.
科学领域:
- 儿科神经学 儿科神经学
- 自闭症谱系障碍研究研究
- 营养神经科学 营养神经科学
背景情况:
- 大脑叶酸缺乏症 (CFD) 与自闭症谱系障碍 (ASD) 有关.
- 阻断脑叶酸进入的自身抗体发生在71%的ASD患者中,导致CFD.
- 莱可沃林增加了脑中的叶酸,可能绕过抗体干扰.
研究的目的:
- 审查目前关于儿科自闭症谱系障碍 (ASD) 的leucovorin的研究.
- 指导临床医生评估和治疗患有ASD和CFD的儿童.
- 提供leucovorin在ASD中的生物学理由,证据和局限性的概述.
主要方法:
- 关于leucovorin和自闭症谱系障碍的研究的文献综述.
- 关于ASD中脑叶酸缺乏症 (CFD) 的证据分析.
- 检查临床试验数据和专家建议.
主要成果:
- 一些研究表明,leucovorin可以降低具有特定自身抗体的非语言自闭症儿童的沟通缺陷.
- 其他研究报告说,在ASD中使用leucovorin治疗没有改善症状.
- 美国儿科学会 (AAP) 目前不推用于ASD的leucovorin.
结论:
- 由于社交媒体和政策利益,人们注意到对ASD的leucovorin处方的要求增加.
- 临床医生需要平衡地了解leucovorin在儿童ASD中的潜在益处和局限性.
- 需要进一步的研究来澄清leucovorin在管理ASD中的功效和作用.
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