由于先天性肺形而接受胸切除术肺切除的儿童的长期结果
Marie Todo1,2, Koichi Deguchi1, Hiroomi Okuyama3
1Department of Pediatric Surgery, Graduate School of Medicine, Osaka University, 2-15 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Surgery today
|February 11, 2026
概括
由于先天性肺形而接受胸切除术的儿童长期减少了肺功能,持续出现喘状症状和肌肉骨问题. 然而,他们的健康相关生活质量 (HRQOL) 与健康同龄人相比仍然相当.
科学领域:
- 儿科手术 儿科手术
- 胸部外科手术 胸部外科手术
- 肺部病理学 肺部病理学
背景情况:
- 先天性肺形 (CLMs) 是儿童呼吸系统问题的重要原因.
- 通过胸腔切除手术切除是CLM的常见治疗方法.
- 针对CLM的儿科胸切除术后的长期结果需要进一步调查.
研究的目的:
- 为了评估长期的肺功能,并发症率和与健康相关的生活质量 (HRQOL) 在儿童后,为CLMs胸切除术.
- 为了评估术后肺部和肌肉骨疾病的持续性.
- 将结果与健康对照进行比较.
主要方法:
- 对27名为CLM进行胸切除术的儿童 (1992-2017年) 的回顾性评估,随访时间>5年.
- 分析了术后的肺功能测试 (预测生命能力的百分比[%VC],1秒内预测的强迫呼气体积的百分比[%FEV1],FEV1/FVC比率).
- 儿科生活质量库存 (PQLI) 用于评估HRQOL和发病率.
主要成果:
- 肺功能 (%VC和FEV1/FVC) 明显低于对照组,FEV1%低于正常范围,没有显著的纵向变化.
- 类似喘的症状影响了37.0%的患者,持续到青春期;肌肉骨疾病发生在33.3%,包括5例pectus excavatum病例.
- 与健康相关的生活质量 (HRQOL) 与健康对照没有显著差异.
结论:
- 与健康同龄人相比,为CLM进行胸切除术的儿童经历了持久的,显著降低的肺功能.
- 尽管有长期的肺部和肌肉骨并发症,主观HRQOL并没有受到不利影响.
- 这些发现凸显了这一患者群体中呼吸道和肌肉骨健康的长期监测和管理的需要.
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