相关实验视频

Updated: Feb 12, 2026

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS
06:49

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS

Published on: October 6, 2015

21.0K

用托弗森治疗SOD1-ALS会导致非进展性慢性ALS - - 来自冰岛的一系列病例

Bjorn Logi Thorarinsson1, Olafur Arni Sveinsson2,3, Agust Hilmarsson2

  • 1Landspitali University Hospital Reykjavik, Skaftahlid 24, 105, Reykjavik, Iceland. bjornlth@landspitali.is.

Journal of neurology
|February 11, 2026
PubMed
概括

用tofersen治疗,一种反感性寡核酸,在四名SOD1突变异位侧硬化症 (ALS) 患者中停止了疾病进展并改善了运动功能. 这种精准医学方法导致了非进展性ALS表型,并降低了神经丝光链水平.

关键词:
这就是ALS.这是一种反意义的寡核酸.神经纤维光电链的链条超氧化物脱酶 1 超氧化物脱酶托弗森的意思是说.

更多相关视频

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS12:43

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS

Published on: February 21, 2011

36.0K
ALS - Motor Neuron Disease: Mechanism and Development of New Therapies15:48

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

Published on: July 29, 2007

10.1K

相关概念视频

Resistors In Series01:10

Resistors In Series

A resistor is an ohmic device that limits the flow of charge in a circuit. Most circuits have more than one resistor. If several resistors are connected together and connected to a battery, the current supplied by the battery depends on the equivalent resistance of the circuit. The equivalent resistance of a combination of resistors depends on both their individual values and how they are connected. The simplest combination of resistors is the series combination. 
In a series circuit, the...
6.7K
Series Resonance01:17

Series Resonance

The RLC circuit impedance is defined as the ratio of the supply voltage to the circuit current. Resonance in such a circuit occurs when the imaginary part of this impedance equals zero. This specific condition means that the inductive reactance is exactly equal to the capacitive reactance. The frequency at which this happens is known as the resonant frequency. Mathematically, the resonant frequency is inversely proportional to the square root of the product of the inductance (L) and capacitance...
877
Series and Parallel Capacitors01:14

Series and Parallel Capacitors

Capacitors, fundamental components in electronic circuits, can be connected in series and/or parallel configurations. Each configuration has different impacts on the overall behavior of the circuit.
First, consider capacitors connected in series to a battery. In this configuration, the plate connected to the battery's positive terminal develops a positive charge, while the plate attached to the negative terminal becomes negatively charged. An equal magnitude of charge is induced on the...
9.7K
Trigonometric Fourier series01:17

Trigonometric Fourier series

Fourier series is a foundational mathematical technique that decomposes periodic functions into an infinite series of sinusoidal harmonics. This method enables the representation of complex periodic signals as sums of simple sine and cosine functions, facilitating their analysis and interpretation in various fields, including signal processing, acoustics, and electrical engineering.
The trigonometric Fourier series specifically expresses a periodic function with a defined period T using sine...
825
Convergence of Fourier Series01:21

Convergence of Fourier Series

The Fourier series is a powerful mathematical tool for representing periodic signals as an infinite sum of complex exponentials. In practice, this infinite series is truncated to a finite number of terms, yielding a partial sum. This truncation makes the approximation of the signal feasible but introduces certain challenges, particularly near discontinuities, known as the Gibbs phenomenon.
The Gibbs phenomenon refers to the persistent oscillations and overshoots that occur near discontinuities...
437
Series R—L Circuit Transients01:22

Series R—L Circuit Transients

In a series resistor-inductor (R-L) circuit, closing the switch at the start of the time period simulates a three-phase short circuit, a fault condition where all three phases of an unloaded synchronous machine are short-circuited. When there is no fault impedance and no initial current, the initial voltage is determined by the phase angle of the source voltage.
Using Kirchhoff's Voltage Law (KVL) to analyze this circuit helps determine the total asymmetrical fault current, which consists...
431