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暴露于压力,应对压力,以及非常早产新生儿的短期结果:一项国家队列研究
Judith A Ten Barge1, Naomi J Meesters2, Manon Benders3
1Department of Neonatal and Pediatric Intensive Care, Division of Neonatology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands. j.tenbarge@erasmusmc.nl.
European journal of pediatrics
|February 11, 2026
概括
新生儿重症监护室 (NICU) 的压力影响非常早产的婴儿.
科学领域:
- 新生儿生理学 新生儿生理学
- 压力反应应对压力.
- 内分泌学 在内分泌学.
背景情况:
- 非常早产的新生儿在NICU中经历了重要的日常压力因素.
- 暴露于压力和皮质醇反应的改变与这些婴儿的不良结果有关.
研究的目的:
- 为了检查NICU压力因素,尿皮质醇水平和非常早产新生儿的短期结果之间的关系.
- 了解下丘脑-垂体-上腺 (HPA) 轴的发展和与妊娠年龄相关的应激反应.
主要方法:
- 一项多中心队列研究 (HIPPO) 涉及446名新生儿 (妊娠年龄<29周).
- 在前28天收集关于日常应激暴露和结果的前性数据.
- 尿中皮质醇水平测量在产后第8天和第28天作为压力反应的标志物.
主要成果:
- 在更多的早产婴儿中,皮质醇水平通常更高,具有显著的变化.
- 皮质醇对压力的反应因妊娠年龄而异:在怀孕27周以上的婴儿中,皮质醇随着压力而增加,但在最早产的婴儿中降低.
- 在死亡或患有严重疾病的新生儿中观察到更高的皮质醇水平,但与结果无独立关联.
结论:
- 尿中皮质醇水平受到妊娠年龄的影响,缓解了高皮质醇和新生儿发病率/死亡率之间的联系.
- 了解早产儿的压力反应对于开发有效的减压策略至关重要.
- 减少压力对于保护早产儿未来健康至关重要.
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