针对炎症性肠病的益生菌输送系统:最近的进展和翻译挑战
Haofan Liu1,2,3, Lina Yang1, Sicheng Huang1
1College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, China.
益生菌输送系统通过改善肠道健康来治疗炎症性肠病 (IBD) 是有前途的. 克服稳定性和生物可用性的挑战是IBD治疗临床成功的关键.
科学领域:
- 胃肠病学 胃肠病学
- 生物技术是生物技术.
- 微生物学 微生物学
背景情况:
- 炎症性肠病 (IBD) 是一种慢性胃肠道疾病,影响生活质量.
- 益生菌通过调节肠道微生物群和减少炎症,为IBD提供治疗潜力.
- 目前的益生菌应用受到胃肠道中生存率和生物可用性差的阻碍.
研究的目的:
- 审查肠道中益生菌作用的机制.
- 讨论有关IBD益生菌输送系统的进展.
- 为这些交付系统概述评估策略.
主要方法:
- 对益生菌机制和输送平台 (乳液,纳米颗粒,水凝,微球,纳米纤维) 的系统审查.
- 在体外和临床前评估方法的概述 (IBD动物模型,组织学,成像学,免疫学,微生物群分析).
主要成果:
- 有效的输送系统保护益生菌,增强稳定性和生物可用性.
- 优化的输送系统提高了对肠道炎症的治疗疗效.
- 显著的障碍阻碍了临床翻译,包括安全性,质量控制,制造和监管问题.
结论:
- 精心设计的益生菌输送系统有可能用于IBD治疗.
- 解决制造,监管和标准化方面的挑战对于临床翻译至关重要.
- 需要进一步的研究来推进益生菌输送系统的IBD预防和治疗.
更多相关视频
08:27Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
Published on: September 20, 2018
07:10Author Spotlight: Development and Application of a Canine IBD Gut-on-a-Chip Model for 3D Intestinal Morphogenesis Studies
Published on: February 9, 2024
相关概念视频
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
