评估系统性内皮功能障碍在青光眼的亚型和伪剥皮使用光聚光学基流介导扩张的流动介导扩张.
Fatumatuz Zehra Karakuzu1, Murat Buyukaksu2, Fatih Aslan3
1Department of Molecular Medicine, Graduate School, Alanya Alaaddin Keykubat University, Antalya, Turkey.
International ophthalmology
|February 11, 2026
概括
系统性内皮功能障碍在初级开角玻璃眼 (POAG) 和伪剥皮玻璃眼 (PEXG) 患者中更为明显. 基于光聚缩的流量介导扩张 (PPG-FMD) 提供了一种新的,非侵入性的方法来评估青光眼的血管健康.
科学领域:
- 眼科医生 眼科 眼科
- 血管生物学 血管生物学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 玻璃眼,包括初级开角玻璃眼 (POAG),伪脱皮玻璃眼 (PEXG) 和伪脱皮综合征 (PEXS),是不可逆转失明的主要原因.
- 系统性内皮功能障碍越来越多地被认为是各种血管疾病的促成因素.
- 评估内皮功能的非侵入性方法可能有助于了解青光眼病理生理学和识别有风险的个体.
研究的目的:
- 为了评估POAG,PEXG和PEXS患者的全身内皮功能障碍,使用基于光透膜学的流量介导扩张 (PPG-FMD).
- 检查内皮功能与眼睛结构参数 (如眼内压 (IOP),状细胞复合体 (GCC) 厚度和外皮皮质视网膜神经纤维层 (RNFL) 厚度) 之间的关联.
主要方法:
- 一项涉及55名参与者的前性横截面研究:POAG (n=12),PEXG (n=14),PEXS (n=16) 和对照 (n=13).
- 使用PPG-FMD非侵入性测量全身内皮功能,通过反应性高血压期间的脉冲幅度变化评估血管反应性.
- 包括IOP,GCC厚度和RNFL厚度在内的眼科参数使用光谱域OCT进行了评估.
主要成果:
- 与对照组相比,POAG (85.4±6.0%) 和PEXG (82.5±4.3%) 组的PPG-FMD扩张指数平均值显着较低 (124.5±10.1%,p<0.001).
- 皮克斯集团的PPG-FMD没有显著减少.
- 内皮功能与GCC (r=0.311,p=0.027) 和RNFL厚度 (r=0.378,p=0.007) 有正相关,与IOP (r=-0.339,p=0.013) 有负相关.
结论:
- 系统性内皮功能障碍在患有青光斑视神经病变的患者中更为明显,特别是PEXG和POAG.
- PPG-FMD技术是一种新的,独立于操作者的,临床上可行的工具,用于评估青光眼患者的血管内皮功能.
- PPG-FMD可以非侵入性地检测青光眼中的全身血管功能障碍,作为IOP和OCT指标的补充标记,用于识别高风险个体.
相关概念视频
Glaucoma: Overview
1.4K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.4K
Cardiomyopathy II: Dilated Cardiomyopathy
589
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
589
Open Angle Glaucoma: Treatment
1.0K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.0K
Adrenergic Receptors: ɑ Subtype
3.0K
Adrenoceptors are classified into α and ꞵ classes based on their potencies to catecholamine agonists. α-adrenoceptors show the following order of catecholamine potency:
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
3.0K
Adrenergic Receptors: β Subtype
3.9K
β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
3.9K
Angle Closure Glaucoma: Treatment
1.3K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.3K


