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在前列腺癌中,冷治疗后的救援放射治疗

F León^1,2, S Moreno-López³, J Mases¹

¹Department of Radiation Oncology, Hospital Clínic of Barcelona, Barcelona, Spain.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

|February 11, 2026

概括

对于前列腺癌,冷治疗后的救援放射治疗提供了持久的控制. 低分离似乎是安全有效的,在本研究中没有观察到增加的毒性.

科学领域:

在瘤学瘤学.
辐射瘤学辐射瘤学
泌尿器科泌尿器科泌尿器科泌尿器科

背景情况:

低温疗法 (CT) 是前列腺癌 (PC) 的新兴主要治疗方法.
对于CT使用,存在有限的指南建议.
救援放射治疗 (sRT) 是CT后PC复发的一个选择.

研究的目的:

评估复发性PC的sRT后CT的毒性,局部控制,生化控制和生存结果.
评估低分离对毒性和结果的影响.

主要方法:

对21名患有复发性PC的CT后患者进行了回顾性分析,这些患者接受了SRT治疗 (2013-2023年).
使用RTOG尺度评估毒性;通过基平方试验比较与分化相关的毒性.
生物化学复发由城标准定义;使用卡普兰-梅尔方法分析生存和局部控制.

主要成果:

随访时间中位数:56个月. 年龄中位数:73岁.
中位数SRT剂量:73.14 Gy; 86%接受激素治疗; 52%接受过低分化.
剧烈的GU毒性 (G2): 23.8% . 慢性GU毒性 (G2/G3):28.6%/9.5%. 这是一个很大的问题. 胃肠道毒性:<5%以上传统和低分化之间的毒性没有显著差异.
平均生存期:108.45个月. 平均操作系统:98个月. 地方控制:90.4%.

结论:

在CT后的sRT可以在精选的前列腺癌患者中实现持久的局部和生化控制.
严重的晚期毒性是可能的,但只发生在很少的病例中.
低分离是一种可行的选择,用于sRT后CT,与这种队列中毒性增加无关.

关键词:

生物化学复发的发生.结冷疗法 (Cryotherapy) 是一种治疗方法.当地复发局部复发前列腺癌是什么意思前列腺癌是什么意思救援辐射疗法救援辐射疗法有毒性有毒性

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