紧急部门发起的布普伦诺芬治疗阿片类药物使用障碍:一项随机临床试验
Gail D'Onofrio1,2,3, Andrew A Herring4,5, Kathryn F Hawk1,3
1Department of Emergency Medicine, Yale School of Medicine, New Haven, Connecticut.
JAMA
|February 11, 2026
概括
延长释放注射布普伦诺芬和舌下布普伦诺芬在7天后显示,阿片类药物使用障碍的治疗参与度相似. 两种配方都被很好地容忍,很少出现急性戒断,即使芬太尼的患病率很高.
科学领域:
- 成 药物 药物 药物 药物
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 阿片类药物使用障碍 (OUD) 是一个主要的公共卫生危机.
- 紧急诊所 (ED) 是启动OUD治疗的关键接触点.
- 延长释放注射布普伦诺芬为难以接触的人群提供了潜在的战略.
研究的目的:
- 为了比较ED启动的7天延长释放注射性布普伦诺啡与口服布普伦诺啡的有效性.
- 作为主要结局,评估7天的治疗参与度.
- 评估二次结果,包括30天的参与,戒断,渴望,非法使用和满意度.
主要方法:
- 多中心随机临床试验,涉及2000名OUD成年患者,呈现EDs.
- 患者接受了24毫克延长释放注射布普伦诺芬或7天的舌下布普伦诺芬.
- 评估了治疗开始,戒断,渴望,非法使用和满意度.
主要成果:
- 延长释放 (40.5%) 和舌下 (38.5%) 布普伦诺芬组之间的7天治疗参与度没有显著差异.
- 观察到类似的30天参与率 (43.8%对44.9%).
- 延长释放布伦诺芬组报告了更低的渴望得分和更少的非法阿片类药物使用日.
结论:
- 发起ED的7天延长释放注射性布普伦诺芬在初始OUD治疗中不低于舌下布普伦诺芬.
- 这两种配方均耐受性良好,安全,急性戒断率低.
- 延长释放注射布普伦诺芬可能在减少渴望和非法阿片类药物使用方面具有优势.
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