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在DNA复制和DNA损伤反应过程中,人类DNA聚合酶delta与p12变体的差异性功能

Jugal Kishor Sahu1,2, Ipsita Subhadarsini1,2, Shweta Thakur1

  • 1Laboratory of Genomic Instability and Diseases, Department of Infectious Disease Biology, Institute of Life Sciences, Bhubaneswar-751023, India.

Molecular biology of the cell
|February 11, 2026
PubMed
概括

人类DNA聚合酶三角酶 (Polδ) 的最小子单元p12,其两个异构体在维持基因组稳定性方面具有不同的作用. 失去p12会损害DNA复制,并增加对DNA损伤剂的敏感性.

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