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Updated: Feb 13, 2026

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瘤矩阵蛋白质甘氨酸的积累和处理改变了T细胞效应因子的功能,以及对患有寡基转移性结直肠癌的患者免疫治疗的反应

Dustin A Deming1, Sean G Kraus2, Joshua Brand3

  • 1University of Wisconsin-Madison Madison, WI United States.

Clinical cancer research : an official journal of the American Association for Cancer Research
|February 11, 2026
PubMed
概括

在结直肠癌 (CRC) 中的维西康 (VCAN) 积累阻碍了T细胞的活动. 然而,其蛋白质分解 (VPP表型) 与更好的免疫反应和免疫疗法试验中更好的结果相关.

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