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绘制四个肥胖轴-炎症性细胞因子-静脉血栓塞栓症风险景观:双步调解 门德尔随机化分析 两步调解
Rongrong Li1, Hongping Luo1, Ye Tian1
1Nursing Department, Tongii Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
一般肥胖和下体脂肪增加静脉血栓栓塞 (VTE) 的风险,而炎症部分介于这些影响. 身体下部的脂肪
科学领域:
- 遗传学 遗传学 是一个
- 流行病学 流行病学
- 心血管疾病 心血管疾病
背景情况:
- 像BMI这样的标准肥胖指标没有区分脂肪分布,限制了静脉血栓栓塞 (VTE) 的因果推断.
- 肥胖是一种异质的疾病,具有不同的脂肪分布模式,影响健康结果.
- 了解导致VTE风险的特定脂肪储存对于有针对性的预防至关重要.
研究的目的:
- 使用孟德尔随机化 (MR) 调查不同肥胖轴和VTE风险之间的因果关系.
- 探索炎症性细胞因子在肥胖和VTE之间的关联中的调解作用.
- 为了区分由一般肥胖引起的VTE风险与下体脂肪分布.
主要方法:
- 利用全基因组显著仪器对四个MRI定义的脂肪轴:一般肥胖,下体脂肪,肌肉主导和外围脂肪.
- 评估了VTE及其亚型 (深静脉血栓症 (DVT) 和肺栓塞 (PE)) 使用FinnGen-R12的数据.
- 采用逆变量加权,补充MR估计器和两步调解MR来分析因果关系和调解途径.
主要成果:
- 一般肥胖轴显著增加了VTE,DVT和PE的风险 (所有P<0.05).
- 下体脂肪轴也增加了静脉瘤和深肠瘤的风险 (PFDR <0.05).
- CTACK/CCL27,Beta-NGF和MCP-3等炎症调解剂部分解释了一般肥胖和VTE/PE之间的关联.
结论:
- 炎症部分介于一般肥胖和VTE之间的联系,包括其亚型.
- 身体下部脂肪的积累主要通过局部静脉血液动力学途径导致静脉瘤/静脉瘤风险.
- 这项研究强调了在VTE风险评估和预防策略中考虑脂肪分布的重要性.
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