在土耳其成年人中使用reflimR进行例行生物化学测试的参考间隔的验证
Levent Deniz1, Ozlem Demirelce2
1Department of Medical Biochemistry, University of Health Sciences Türkiye, Istanbul Training and Research Hospital, Istanbul, Türkiye.
PloS one
|February 11, 2026
概括
这项研究使用reflimR方法验证了土耳其成年人的参考间隔 (RI),发现由于人口差异而与制造商RI存在差异. 该reflimR算法提供了一种可访问的方式来计算和验证RI.
科学领域:
- 临床生物化学 临床生物化学
- 实验室医学 实验室医学
- 人口健康 人口健康
背景情况:
- 确定准确的参考间隔对于解释临床实验室试验结果至关重要.
- 制造商提供的RI可能不准确地反映多样化的群体,需要进行本地验证.
- 该reflimR方法为间接RI估计和验证提供了一种新方法.
研究的目的:
- 为了验证在成年土耳其人群中进行19项常规生物化学测试的参考间隔 (RIs).
- 用reflimR方法获得的RI与制造商提供的RI进行比较.
- 评估reflimR算法的性能与其他间接RI估计方法相比.
主要方法:
- 利用reflimR算法对19个生物化学参数进行RI评估,这些参数在Beckman Coulter分析仪上进行分析.
- 在男性和女性的RI估计中采用了五种间接方法 (reflimR,refineR,KOSMIC,Hoffmann,Bhattacharya).
- 应用了一个基于RI极限验证的允许不确定性的交通信号算法.
主要成果:
- 根据reflimR计算的76个RI限值中,有40个被接受,21个需要检查,15个根据制造商值被拒绝.
- 通过reflimR方法,除了ALT,GGT和总 bilirubin外,其他间接方法的结果与一般一致.
- 验证失败突出了人口之间潜在的种族,性别,年龄和地理差异.
结论:
- 该reflimR算法为计算和验证RI提供了一个快速和易于使用的工具.
- 在RI的差异强调了人口特定验证的重要性.
- 诸如种族和人口统计等因素显著影响RI的建立.
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