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Updated: Feb 13, 2026

Isolation of Primary Human Proximal Tubule Epithelial Cells and Their Use in Creating a Microphysiological Model of the Renal Proximal Tubule
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Published on: May 9, 2025

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代谢性酸症会导致Fanconi-like综合征,细胞内交通缺陷和近接管管的功能障碍

J Christopher Hennings1, Keerthana S Murthy1, Nicolas Picard2

  • 1Institute of Human Genetics, Jena University Hospital, Friedrich Schiller University, 07747 Jena, Germany.

Science translational medicine
|February 11, 2026
PubMed
概括

远距离管酸性 (dRTA) 可能会导致Fanconi类综合征由于近道管的功能障碍. 酸化会损害内溶性体的运输,导致脏损伤,但二碳酸盐疗法可以逆转这些影响.

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