评估易受伤害的老年人调查-13和 FIL 老年人的老年评估具有侵略性淋巴瘤
P Connor Johnson1,2, Richard A Newcomb1,2, Ryan D Nipp3
11Mass General Brigham Cancer Institute, Boston, MA.
Journal of the National Comprehensive Cancer Network : JNCCN
|February 11, 2026
概括
易受伤害的老年人调查-13 (VES-13) 有效地选具有侵略性非霍奇金淋巴瘤 (aNHL) 的老年人风险. 这个简短的工具在预测不良结果方面显示出与综合老年病评估相似的准确性.
科学领域:
- 老年瘤学 老年瘤学
- 血液性恶性瘤 血液性恶性瘤
- 临床评估工具 临床评估工具
背景情况:
- 侵袭性非霍奇金淋巴瘤 (aNHL) 主要影响老年人.
- 老年人评估 (GA) 预测了生存和毒性,但由于后勤挑战,其利用率不足.
- 该研究调查了脆弱老年人调查-13 (VES-13) 和老年aNHL患者的全面GA的实用性.
研究的目的:
- 评估VES-13查工具与老年NHL患者的临床结果之间的关联.
- 为了比较VES-13的有效性与Fondazione Italiana Linfomi (FIL) 的综合老年病学评估 (GA).
- 确定VES-13的敏感性和特异性,以识别有毒性,住院和死亡风险的患者.
主要方法:
- 这是一项对105名65岁以上的成年人进行的纵向研究,他们为aNHL开始化疗免疫治疗.
- 使用FIL GA (适合,不适合,脆弱) 和VES-13 (连续和二分法) 评估的脆弱性.
- 后勤回归分析了VES-13与毒性,住院,生活质量 (QoL) 下降和死亡率之间的关联;计算了灵敏度/特异性.
主要成果:
- VES-13得分与增加的毒性 (OR 1.18),非计划住院 (OR 1.16),QoL下降 (OR 1.22) 和1年死亡率 (OR 1.49) 有显著的相关性.
- 在预测1年内死亡时,VES-13显示出100%的灵敏度.
- 在预测毒性和死亡率方面,VES-13对FIL GA的敏感性和特异性相似.
结论:
- 在NHL的老年人中,VES-13评分是生存,毒性,医疗保健利用率和QoL下降的有价值预测指标.
- VES-13的性能与全面的GA相提并论,这表明它作为一种实际的选工具的实用性.
- 实施VES-13可以帮助识别高风险患者,使及时干预和个性化治疗策略成为可能.
相关概念视频
Aggression
30.4K
Humans engage in aggression when they seek to cause harm or pain to another person. Aggression takes two forms depending on one’s motives: hostile or instrumental. Hostile aggression is motivated by feelings of anger with intent to cause pain; a fight in a bar with a stranger is an example of hostile aggression. In contrast, instrumental aggression is motivated by achieving a goal and does not necessarily involve intent to cause pain (Berkowitz, 1993); a contract killer who murders for...
30.4K
Surveys
17.0K
Often, psychologists develop surveys as a means of gathering data. Surveys are lists of questions to be answered by research participants, and can be delivered as paper-and-pencil questionnaires, administered electronically, or conducted verbally. Generally, the survey itself can be completed in a short time, and the ease of administering a survey makes it easy to collect data from a large number of people.
17.0K
Introduction to Surveying, Plane Surveying and Geodetic Surveys
1.1K
Surveying is the art and science of mapping the earth's surface. It involves measuring distances, angles in horizontal or vertical directions, and levels to understand the shape and size of land features. Surveying techniques are essential for various tasks, such as identifying the levels of a land area with reference to a specific point, and mapping undulations and water bodies.There are two main types of surveying: plane surveys and geodetic surveys. Plane surveys assume the earth is flat,...
1.1K
Errors and Mistakes in Surveying
738
Errors and mistakes in surveying refer to inaccuracies in measurements and data recording. The errors are deviations from the actual value caused by human sensory limitations, equipment flaws, or environmental effects. These errors are typically unintentional and can result from the inherent imperfections in the instruments used, atmospheric conditions, or the observer’s inability to perceive exact measurements. On the other hand, mistakes are caused by the surveyor's lack of...
738
Types of Surveys
374
Surveys are essential for marking property boundaries near water bodies. Different types of surveys are defined, each with its own function. Land surveys mark the property boundaries, while route surveys determine the position of properties on nearby highways. Topographic surveys create maps by capturing the three-dimensional features of the land. Hydrographic surveys focus on the shapes of underwater areas and the movement of streams through the properties. Mine surveys determine the relative...
374
Survey Safety
418
Surveying near highways, rough terrain, or power lines involves significant risks. Working along highways is particularly dangerous and requires the use of warning signs and flagmen. It is safest to avoid working directly on roads and use offsets whenever possible. When highway work is unavoidable, it must follow all safety guidelines. Surveyors should wear bright clothing, such as orange reflective vests, to ensure visibility to motorists, coworkers, and hunters. In construction zones, wearing...
418


