种族对退伍军人生存和治疗的影响 退伍军人治疗转移性割抵抗性前列腺癌
Danielle Candelieri-Surette1,2, Nina Cheranda3,4, JongSoo Lee1
11University of Massachusetts Lowell, Lowell, MA.
Journal of the National Comprehensive Cancer Network : JNCCN
|February 11, 2026
概括
患有转移性割抵抗性前列腺癌 (mCRPC) 的黑人退伍军人在接受雄激素受体通路抑制剂 (ARPI) 治疗后的寿命更长. 然而,与白人患者相比,黑人患者的诊断年龄较小,总体寿命较短.
科学领域:
- 在瘤学瘤学.
- 健康差异 在健康上的差异
- 前列腺癌研究 研究前列腺癌
背景情况:
- 黑人面临更高的前列腺癌发病率和死亡率.
- 关于转移性割抵抗性前列腺癌 (mCRPC) 治疗顺序的文学论文有限,涉及种族.
- 了解基于种族的治疗差异对于优化护理和改善整体存活率至关重要.
研究的目的:
- 根据种族和初始雌激素受体通路抑制剂 (ARPI) 治疗,评估mCRPC老兵的生存结果.
- 为了比较黑人和白人退伍军人与mCRPC之间的整体存活率 (OS).
- 为了调查abiraterone对ENZALUTAMIDE对不同种族群体的OS的影响.
主要方法:
- 对mCRPC退伍军人 (白人或黑人) 的回顾性观察队列研究.
- 纳入标准:在2011年1月1日至2024年3月12日期间诊断mCRPC,接受了阿比拉或恩扎胺治疗.
- 主要结局:从诊断和治疗开始测量整体存活期 (OS);使用Kaplan-Meier和Cox模型进行分析.
主要成果:
- 包括12,355名患者;黑人患者的诊断年龄小于4岁 (71.77岁与75.60岁).
- 黑人患者的PSA和查尔森并发症指数得分较高.
- 黑人患者 (36.3 vs 31个月) 和接受恩扎胺 (28 vs 23.7个月) 的患者的中位寿命更高.
结论:
- 接受ARPI治疗的mCRPC的黑人退伍军人在mCRPC诊断后的生存时间大约长了6个月.
- 与白人患者相比,黑人患者的整体寿命缩短了约3年.
- 瘤生物学中的潜在差异可能会解释黑人个体的早期发病和更好的治疗反应.
相关概念视频
Treatment Resistant Cancers
3.8K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
Cancer Survival Analysis
774
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
774
RACE - Rapid Amplification of cDNA Ends
7.3K
Rapid Amplification of cDNA Ends, or RACE, is one of the most effective methods to obtain a full-length cDNA from an mRNA sequence between a known internal region to the unknown sequence at the 5’ or 3’ end. The unknown region is cloned in the cDNA by a gene-specific primer that binds the known end, and a hybrid primer that attaches a predefined anchor sequence to the unknown end of the cDNA. The sequence in between is amplified by PCR with an anchor primer and a gene-specific...
7.3K
Survival Curves
732
Survival curves are graphical representations that depict the survival experience of a population over time, offering an intuitive way to track the proportion of individuals who remain event-free at each time point. These curves are widely used in fields such as medicine, public health, and reliability engineering to visualize and compare survival probabilities across different groups or conditions.
The Kaplan-Meier estimator is the most common method for constructing survival curves. This...
The Kaplan-Meier estimator is the most common method for constructing survival curves. This...
732
Survival Tree
436
Survival trees are a non-parametric method used in survival analysis to model the relationship between a set of covariates and the time until an event of interest occurs, often referred to as the "time-to-event" or "survival time." This method is particularly useful when dealing with censored data, where the event has not occurred for some individuals by the end of the study period, or when the exact time of the event is unknown.
Building a Survival Tree
Constructing a...
Building a Survival Tree
Constructing a...
436
Impact of Groups on Groups
262
Social psychologists analyze how groups influence one another, shaping social structures and interactions through both cooperation and competition. These dynamics manifest in various ways, ranging from economic partnerships to intergroup conflicts that shape societal structures and perceptions.Cooperation and Competition in Intergroup RelationsIntergroup relationships vary across contexts, sometimes fostering cooperation and mutual benefit while at other times leading to conflict and...
262


