全国三气呼吸测试和与症状相关联的现实世界研究
Mark Pimentel1,2, Gabriela Leite2, LiJin Joo2
1Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai, Los Angeles, CA.
Journal of clinical gastroenterology
|February 11, 2026
概括
三气呼吸测试显示,硫化 (H2S) 与腹和症状严重程度增加有关. 甲 (CH4) 与便秘相关,而 (H2) 也表明腹,这表明H2S是胃肠道疾病的关键指标.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 诊断测试 诊断测试 诊断测试
背景情况:
- (H2) 和甲 (CH4) 呼吸测试 (BT) 分别诊断小肠细菌过度生长 (SIBO) 和便秘.
- 硫化 (H2S),第三种微生物衍生的气体,最近被添加到BT中,并与腹有关.
- 这项研究评估了全国范围的3-气体BT,以将气体水平与胃肠道 (GI) 症状相关联.
研究的目的:
- 在一个大规模的全国性队列中评估3气体BT (H2,CH4,H2S) 的诊断效用.
- 为了比较特定气体水平和报告的胃肠道症状之间的相关性.
- 为了确定不同BT基质 (葡萄糖与乳糖) 的灵敏度.
主要方法:
- 6000名受试者在家中接受了3-气体BT,并填写了症状问卷.
- 测量了H2,CH4和H2S水平,定义了SIBO,肠道甲素过度生长 (IMO) 和肠道硫化物过度生产 (ISO).
- 机器学习 (UMAP) 分析了气体相互作用和症状相关性.
主要成果:
- 分析了3004名受试者;胀气是BT最常见的原因.
- 较高的H2S水平与腹,急性和腹痛的增加有很强的相关性.
- 肠道硫化物 (ISO) 的过度产生与更大的腹,急性,胀气和整体症状严重程度有关,特别是单独存在时.
结论:
- H2,CH4和H2S与特定的胃肠道症状有独特的关联:CH4与便秘,H2S与腹和整体严重性有关.
- H2S水平和ISO似乎是严重胃肠道疾病的重要指标.
- 乳酪糖在检测症状性SIBO时可能比葡萄糖更敏感.
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