瘤亚克隆和T细胞动态的演变是沃尔登斯特罗姆巨型球蛋白血症中易布鲁替尼的可变反应的基础

Hao Sun1, Romanos Sklavenitis Pistofidis2, Shirong Liu3

  • 1Dana-Farber Cancer Institute, Boston, Massachusetts, United States.

Blood
|February 11, 2026
PubMed
概括

这项研究揭示了沃尔登斯特罗姆巨球蛋白血症 (WM) 细胞在ibrutinib治疗下如何演变,确定了与反应或进展相关的独特模式. 一个新的WIP评分预测了治疗成功,并强调LYN作为耐药性目标.

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