柏柏林通过调节M1/M2巨细胞极化和T辅助细胞 (Th1/Th2) 的细胞因子平衡来缓解先兆子症
Ailan Yin1, Yuwen Qiu1, Yunfang Wang1
1Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou, China.
British journal of pharmacology
|February 11, 2026
概括
柏柏林治疗通过调节免疫反应和肠道微生物群,改善了小鼠的孕前 (PE) 症状. 这种天然化合物通过向炎症和微生物失衡,显示出治疗PE的前途.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 药理学 药理学 是一个学科.
背景情况:
- 孕前 (PE) 是一种与免疫失衡,炎症和肠道失调相关的妊娠疾病,导致孕产妇和胎儿并发症.
- 目前对PE的治疗方法有限,这凸显了对新型治疗策略的需求.
研究的目的:
- 调查Berberine的治疗潜力,一个来自Coptidis Rhizoma的化合物,在一个LPS诱导的先兆子症小鼠模型中.
- 评估柏柏林对免疫调节和PE肠道微生物群组成的影响.
主要方法:
- 使用脂多糖 (LPS) 诱导怀孕小鼠出现妊娠前,然后用柏柏林治疗.
- 评估生理学参数,胎盘组织学,细胞因子概况和肠道微生物群.
- 在体外测试中,研究了柏柏林对巨细胞两极分化和炎症反应的影响.
主要成果:
- 柏柏林治疗显著降低了血压,蛋白尿和胎盘损伤,同时改善了胎儿和胎盘体重.
- 柏柏林通过调节巨细胞极化 (M1/M2) 和抑制炎症标记物来恢复Th1/Th2平衡.
- 肠道微生物群分析显示多样性增加和组成变化,柏柏林促进有益细菌和调节代谢途径.
结论:
- 柏柏林通过调节免疫反应和肠道微生物群,证明了对子宫前的多目标治疗潜力.
- 这些发现表明,柏柏林可以通过其对炎症和肠道微生物群的影响来作为治疗妊娠前的有价值药物.
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