下一代传染病基因疗法:进展,挑战和未来方向
Maryam Fattahi1, Fatemeh Pirbadami2, Tahereh Motallebirad3
1Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Journal of infection and public health
|February 11, 2026
概括
下一代基因疗法对治疗艾滋病毒和HBV等传染病以及对抗抗菌素耐药性的治疗有前途. 挑战包括交付,安全和公平获取,需要进一步的研究和开发.
科学领域:
- 传染病和微生物学 传染病和微生物学
- 遗传学和基因组学 在
- 生物技术是生物技术.
背景情况:
- 抗菌素耐药性和传统治疗方法的局限性需要新的治疗策略.
- 基因疗法代表着对抗持久性和耐药性传染病原体的有希望的前沿.
- 艾滋病毒,HBV,HPV和多药耐药 (MDR) 病原体对全球健康构成重大挑战.
研究的目的:
- 系统地审查下一代传染病基因疗法的最新进展.
- 评估基因治疗方法的疗效,挑战和未来前景.
- 综合关于CRISPR,菌体和RNAi在抗击HIV,HBV,HPV和MDR病原体方面的发现.
主要方法:
- 在主要数据库中 (2015-2025) 系统地搜索文献,遵守PRISMA指南.
- 包括114项经过同行评审的研究,使用混合方法评估工具 (MMAT) 进行评估.
- 对治疗策略,疗效,挑战和未来方向的数据进行主题综合.
主要成果:
- 基于CRISPR的基因组编辑在早期试验中显示出HIV缓解的潜力.
- 工程菌体和菌体衍生的脱聚酶对MDR细菌和生物膜表现出有效性.
- RNA干扰 (RNAi) 有效地沉默了乙型肝炎病毒 (HBV) 的复制.
- 确定的挑战包括非目标效应,免疫性,可扩展性和交付障碍.
结论:
- 基因疗法为治疗传染病提供了巨大的潜力,包括那些由耐药病原体引起的疾病.
- 进一步的研究对于克服安全性,有效性和交付挑战至关重要.
- 确保平等地获得这些先进疗法,特别是在低收入和中等收入国家,仍然是一个关键的未来方向.
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