儿童类固醇代在上腺留在精髓中
Tsubasa Shironomae1, Yuto Yamazaki2, Shinako Takeda3
1Department of Urology, Miyagi Children's Hospital, Sendai, Japan; Department of Anatomic Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan.
The Journal of surgical research
|February 11, 2026
概括
儿科的上腺在精髓中休息,表现出正常的类固醇生成,胎儿上腺皮层在婴儿期存在,并且随着年龄的增长而减少. 阿尔多激素的生物合成可能不同于eutopic上腺.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 手术病理学手术病理学
- 类固醇的产生.
背景情况:
- 上腺休息是在精髓中发现的异位上腺组织.
- 评估这些残留物中的类固醇生成对于了解儿科上腺功能至关重要.
研究的目的:
- 为了研究小儿类固醇生成和雄激素效应,上腺在精髓中休息.
主要方法:
- 对于精子带质量的儿科外科探索的回顾性审查.
- 在切除的上腺残留物中,对类固醇酶,雄激素受体和Ki-67的免疫组织化学分析.
主要成果:
- 在9名儿科患者中发现了10个上腺休息.
- 上腺休息显示多个皮质区域,胎儿皮质存在于婴儿期,随着年龄的增长而减少.
- 检测到对关键类固醇酶 (CYP11B2,P450 17A1) 和雄激素受体的免疫活性,根据年龄和区域而异.
- 基-67的扩散标记主要是在婴儿期.
结论:
- 精髓上腺休息中的类固醇生成被认为是正常的,尽管阿尔多的生物合成可能不同于eutopic上腺.
- 上腺休息的与年龄相关的变化包括胎儿皮质的存在和不同的酶表达.
相关概念视频
The Resting Membrane Potential
143.3K
Overview
143.3K
Resting Membrane Potential
22.1K
The relative difference in electrical charge, or voltage, between the inside and the outside of a cell membrane, is called the membrane potential. It is generated by differences in permeability of the membrane to various ions and the concentrations of these ions across the membrane.
The Inside of a Neuron is More Negative
The membrane potential of a cell can be measured by inserting a microelectrode into a cell and comparing the charge to a reference electrode in the extracellular fluid. The...
The Inside of a Neuron is More Negative
The membrane potential of a cell can be measured by inserting a microelectrode into a cell and comparing the charge to a reference electrode in the extracellular fluid. The...
22.1K
Anatomy of the Adrenal Glands
4.9K
The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
4.9K
Adrenal Gland Disorders
3.3K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
3.3K
Resting Potential Decay
6.5K
The resting membrane potential of a neuron (-70mV) is sustained due to the selective ion permeability of the membrane. At the resting potential, the membrane is slightly permeable to ions like sodium (Na+) and chloride (Cl−) and highly permeable to potassium ions (K+). Differences in the ions' concentration inside the cell compared to the outside are maintained by membrane transport proteins like channels and pumps.
At rest, the K+ is the main ion that moves across the membrane...
At rest, the K+ is the main ion that moves across the membrane...
6.5K
Hormones of the Adrenal Glands
5.5K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
5.5K


